2022
DOI: 10.3390/healthcare10102012
|View full text |Cite
|
Sign up to set email alerts
|

Protocols of Investigation of Neonatal Cholestasis—A Critical Appraisal

Abstract: Neonatal cholestasis (NC) starts during the first three months of life and comprises extrahepatic and intrahepatic groups of diseases, some of which have high morbimortality rates if not timely identified and treated. Prolonged jaundice, clay-colored or acholic stools, and choluria in an infant indicate the urgent need to investigate the presence of NC, and thenceforth the differential diagnosis of extra- and intrahepatic causes of NC. The differential diagnosis of NC is a laborious process demanding the accur… Show more

Help me understand this report

Search citation statements

Order By: Relevance

Paper Sections

Select...
2
1
1

Citation Types

0
2
0
2

Year Published

2022
2022
2024
2024

Publication Types

Select...
3
1

Relationship

0
4

Authors

Journals

citations
Cited by 4 publications
(4 citation statements)
references
References 138 publications
(177 reference statements)
0
2
0
2
Order By: Relevance
“…Para Quelhas et al (2022) a icterícia colestática neonatal caracteriza-se por hiperbilirrubinemia conjugada com valor laboratorial maior que 1mg/dl ou17 µmol/L associado à bilirrubina total menor que 5mg/dl ou a fração direta maior que vinte porcento da bilirrubina total sendo esta superior a 5mg/dl. Já Cho e Kim (2019) destacam que o consorcio multi-institucional rede de investigação de doenças hepáticas infantis (ChilDReN) considera colestase com valor de bilirrubina direta maior que 2,0mg/dl.…”
Section: Discussionunclassified
See 1 more Smart Citation
“…Para Quelhas et al (2022) a icterícia colestática neonatal caracteriza-se por hiperbilirrubinemia conjugada com valor laboratorial maior que 1mg/dl ou17 µmol/L associado à bilirrubina total menor que 5mg/dl ou a fração direta maior que vinte porcento da bilirrubina total sendo esta superior a 5mg/dl. Já Cho e Kim (2019) destacam que o consorcio multi-institucional rede de investigação de doenças hepáticas infantis (ChilDReN) considera colestase com valor de bilirrubina direta maior que 2,0mg/dl.…”
Section: Discussionunclassified
“…Distúrbio do metabolismo lipídico (armazenamento) -Síndrome de Wolman (LIPA); doença de Niemann-Pick (NPC 1 e 2); doença de Gaucher tipo II (GBA); Doença de Farber tipo IV (ASAH1). Fonte: Adaptado de Feldman e Sokol (2021) e Quelhas et al (2022).…”
Section: Doenças Hepáticas Metabólicasunclassified
“…Essentially, 33% of patients with a liver biopsy not consistent with BA may still have BA. Imaging modalities including abdominal US, HIDA, endoscopic retrograde cholangiopancreatography (ERCP), magnetic resonance cholangiopancreatography (MRCP), and percutaneous cholecystocholangiography can potentially aid in the diagnosis of BA but are limited by their sensitivity and specificity, requiring additional testing and definitive intraoperative cholangiogram (7,9,(11)(12)(13)(14)(15)(16)(17)(18)(19)(20)(21)(22)(23)(24). The utility of ERCP in the diagnosis of BA was described with a prototype pediatric duodenoscope in 1991, but the current shortages for neonatal duodenoscopes (and the endoscopists skilled in using them) preclude ERCP from being a routine tool in diagnosis (25,26).…”
Section: Discussionmentioning
confidence: 99%
“…Although anicteric newborns or people with normal feces might exhibit NC, it is typically characterized by jaundice, hypocholic stools, and choluria. [1] NC is relatively common, with an incidence of 1:2500 in live births. It can result in serious outcomes and requires prompt intervention.…”
Section: Introductionmentioning
confidence: 99%