Protocol summary and statistical analysis plan for the Targeted Therapeutic Mild Hypercapnia after Resuscitated Cardiac Arrest (TAME) trial

Nichol, Alistair; Bellomo, Rinaldo; Ady, Bridget; Nielsen, Niklas; Hodgson, Carol; Parke, Rachael; McGuinness, Shay; Skrifvars, Markus B.; Barnard, Stephen; Taccone, Fabio; Archer, John S.; Neto, Ary Serpa; Trapani, Tony; Ainscough, Kate; Hunt, Anna; Kutsogiannis, Jim; Eastwood, Glenn M

doi:10.51893/2021.4.oa2

Cited by 4 publications

(4 citation statements)

References 42 publications

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“…An arterial blood gas measure should then be performed as soon as possible after hospital arrival to ensure that P co 2 is in the normal range. Of note, a phase 3 study testing whether mild hypercapnia (P co 2 of 50-55 mm Hg) improves outcomes compared with normocapnia after resuscitation from out-of-hospital cardiac arrest has recently concluded, and the results of that study are awaited with interest.…”

mentioning

confidence: 99%

Lower vs Higher Oxygen Saturation Targets and Survival to Hospital Discharge Among Patients Resuscitated After Out-of-Hospital Cardiac Arrest—Reply

Bernard

Bray

2023

JAMA

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mentioning

confidence: 99%

Lower vs Higher Oxygen Saturation Targets and Survival to Hospital Discharge Among Patients Resuscitated After Out-of-Hospital Cardiac Arrest—Reply

Bernard

Bray

2023

JAMA

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“…The trial protocol and statistical analysis plan were published before the completion of enrollment. 27 All the analyses were performed in the intention-to-treat population, which included all the patients who had undergone randomization except for those who withdrew consent.…”

Section: Discussionmentioning

confidence: 99%

Mild Hypercapnia or Normocapnia after Out-of-Hospital Cardiac Arrest

Eastwood¹,

Nichol²,

Hodgson³

et al. 2023

N Engl J Med

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“…These possibilities also include manual chest compression and bag mask ventilation. Whether mild hypercapnia (PaCO 2 50-55 mm Hg) within the first 24 h after OHCA is associated with a favorable neurological survival after six months is currently being investigated in the Targeted Therapeutic Mild Hypercapnia after Resuscitated Cardiac Arrest (TAME) trial [67]. These findings can impact future initial ICU treatment and are awaited to be published in June 2023.…”

Section: Discussionmentioning

confidence: 99%

Developments in Post-Resuscitation Care for Out-of-Hospital Cardiac Arrests in Adults—A Narrative Review

Katzenschlager

Popp

Wnent

et al. 2023

JCM

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This review focuses on current developments in post-resuscitation care for adults with an out-of-hospital cardiac arrest (OHCA). As the incidence of OHCA is high and with a low percentage of survival, it remains a challenge to treat those who survive the initial phase and regain spontaneous circulation. Early titration of oxygen in the out-of-hospital phase is not associated with increased survival and should be avoided. Once the patient is admitted, the oxygen fraction can be reduced. To maintain an adequate blood pressure and urine output, noradrenaline is the preferred agent over adrenaline. A higher blood pressure target is not associated with higher rates of good neurological survival. Early neuro-prognostication remains a challenge, and prognostication bundles should be used. Established bundles could be extended by novel biomarkers and methods in the upcoming years. Whole blood transcriptome analysis has shown to reliably predict neurological survival in two feasibility studies. This needs further investigation in larger cohorts.

show abstract

Protocol summary and statistical analysis plan for the Targeted Therapeutic Mild Hypercapnia after Resuscitated Cardiac Arrest (TAME) trial

Cited by 4 publications

References 42 publications

Lower vs Higher Oxygen Saturation Targets and Survival to Hospital Discharge Among Patients Resuscitated After Out-of-Hospital Cardiac Arrest—Reply

Lower vs Higher Oxygen Saturation Targets and Survival to Hospital Discharge Among Patients Resuscitated After Out-of-Hospital Cardiac Arrest—Reply

Mild Hypercapnia or Normocapnia after Out-of-Hospital Cardiac Arrest

Developments in Post-Resuscitation Care for Out-of-Hospital Cardiac Arrests in Adults—A Narrative Review

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