Protocol of a Multicenter International Randomized Controlled Manikin Study on Different Protocols of Cardiopulmonary Resuscitation for laypeople (MANI-CPR)

Abstract

IntroductionOut-of-hospital cardiac arrest is one of the leading causes of death in industrialised countries. Survival depends on prompt identification of cardiac arrest and on the quality and timing of cardiopulmonary resuscitation (CPR) and defibrillation. For laypeople, there has been a growing interest on hands-only CPR, meaning continuous chest compression without interruption to perform ventilations. It has been demonstrated that intentional interruptions in hands-only CPR can increase its quality. The aim of this randomised trial is to compare three CPR protocols performed with different intentional interruptions with hands-only CPR.Methods and analysisThis is a prospective randomised trial performed in eight training centres. Laypeople who passed a basic life support course will be randomised to one of the four CPR protocols in an 8 min simulated cardiac arrest scenario on a manikin: (1) 30 compressions and 2 s pause; (2) 50 compressions and 5 s pause; (3) 100 compressions and 10 s pause; (4) hands-only. The calculated sample size is 552 people. The primary outcome is the percentage of chest compression performed with correct depth evaluated by a computerised feedback system (Laerdal QCPR).Ethics and dissemination. Due to the nature of the study, we obtained a waiver from the Ethics Committee (IRCCS Policlinico San Matteo, Pavia, Italy). All participants will sign an informed consent form before randomisation. The results of this study will be published in peer-reviewed journal. The data collected will also be made available in a public data repository.Trial registration numberNCT02632500.

Cardiopulmonary Resuscitation Capacity Building Training for High School Students in Martapura, Banjar Regency

“…Rapid responses and early interventions have proven to be critical in the care of patients with OHCA. A key element in the "chain of survival," bystander CPR is one of the first possible treatments an OHCA victim may receive better long-term survival and health-related quality of life (Baldi et al, 2018;Doctor et al, 2017;Fazel et al, 2022;Nas et al, 2019).…”

“…Therefore, many parties, such as the government, independent organizations, activists, and even private companies, are trying to get around this problem. One of them is by utilizing mobile learning technology which is growing rapidly (Ahmed et al, 2022;Baldi et al, 2018;Fazel et al, 2022;Khan et al, 2022;Ko et al, 2021;Zheng et al, 2022). National association organizations engaged in social and humanitarian fields from various countries have developed many mobile learning applications for first aid such as PMI First Aid, First Aid by America Red Cross, First Aid by Kosova Red Cross, and First Aid by British Red Cross.…”

A Multicenter International Randomized Controlled Manikin Study on Different Protocols of Cardiopulmonary Resuscitation for Laypeople

“…The trial was prospectively registered in clinicaltrials.gov (NCT02632500) on December 16, 2015. The protocol and statistical analysis plan were published 20 and are available in Supplemental Digital Content 1 (see PDF, Supplemental Digital Content 1, http://links.lww.com/SIH/A560, which contains the protocol and statistical analysis plan).…”