2020
DOI: 10.1007/978-1-0716-0471-7_4
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Protocol for the Use of the Ketogenic Diet in Preclinical and Clinical Practice

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Cited by 14 publications
(10 citation statements)
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“…KB include acetylacetate (H3C-CO-CH2-COO-), β-D-hydroxybutyrate (H3C-CHOH-CH2-COO-) and volatile acetone (H3C-CO-CH3). KD are high-fat, moderate-protein and lowcarbohydrate (usually less than 40 g/day) diets 18 , and induce a surge in KB, in particular 3hydroxybutyrate (3HB). This increase in 3HB also occurs after fasting, favoring mitochondrial respiration rather than glycolysis for energy metabolism.…”
Section: Introductionmentioning
confidence: 99%
“…KB include acetylacetate (H3C-CO-CH2-COO-), β-D-hydroxybutyrate (H3C-CHOH-CH2-COO-) and volatile acetone (H3C-CO-CH3). KD are high-fat, moderate-protein and lowcarbohydrate (usually less than 40 g/day) diets 18 , and induce a surge in KB, in particular 3hydroxybutyrate (3HB). This increase in 3HB also occurs after fasting, favoring mitochondrial respiration rather than glycolysis for energy metabolism.…”
Section: Introductionmentioning
confidence: 99%
“…Diese positiven metabolischen Effekte auf hormoneller Ebene bei Mäusen scheinen bei Tumorpatienten ähnlich zu sein Dies führt zu einem Anstieg der Ketonkörper, insbesondere von 3-Hydroxybutyrat (3HB). Dieser Zustand des Metabolismus wird als Ketose bezeichnet [68]. Ein Anstieg von 3HB kann auch während des Fastens beobachtet werden.…”
Section: Intermittierendes Fastenunclassified
“…Despite its clinical use for nearly 100 years, how the KD controls seizures remains unknown [12]. KD was used to regulate energy metabolism in order to manage epilepsy [13], beta-hydroxybutyrate is the major bioactive metabolite [14,15]. In this study, we are aimed to explore the role of LRP1 in Epilepsy and whether KD can treat epilepsy caused by LRP1 knockdown by using betahydroxybutyrate.…”
Section: Introductionmentioning
confidence: 99%