Protocol for the China PEACE (Patient-centered Evaluative Assessment of Cardiac Events) Million Persons Project pilot

Abstract

IntroductionCollection of high-quality data from large populations is considered essential to generate knowledge that is critical to an era of precision medicine. Cardiovascular disease (CVD) is a leading cause of mortality in China and is a suitable focus of an initiative to discover factors that would improve our ability to assess and modify individual risk.Methods and analysisThe pilot phase of China PEACE (Patient-centered Evaluative Assessment of Cardiac Events) Million Persons Project is being conducted during 2014–2015 in four provinces across China to demonstrate the feasibility of a population-based assessment. It is designed to screen 0.4 million community-dwelling residents aged 40–75 years with measurements of blood pressure, height and weight, a lipid blood test, and a questionnaire on cardiovascular-related health status. Participants identified at high risk of CVD receive further health assessments, including ECG, ultrasound scan, blood and urine analysis, and a questionnaire on lifestyle and medical history. Collection of blood and urine samples is used to establish a biobank. High-risk subjects are also counselled with suggestions regarding potential lifestyle changes. In addition, high-risk subjects are followed-up either in a return clinic visit or by telephone interview, with measurement of blood pressure, weight, ECG, and a questionnaire on survival status, hospitalisations and lifestyle. The first 0.1 million participants screened were used to conduct a preliminary analysis, with information on baseline characteristics, health-related behaviours, anthropometric variables, medical history, and prevalence of high-risk subjects.Ethics and disseminationThe central ethics committee at the China National Center for Cardiovascular Disease (NCCD) approved the pilot. Written informed consent is obtained from all participants on entry into the project. Findings will be disseminated in future peer-reviewed papers and will inform strategies aimed at developing precise methods of assessing and modifying risk.Trial registration numberNCT02536456.

Availability, cost, and prescription patterns of antihypertensive medications in primary health care in China: a nationwide cross-sectional survey

“…In MPP, blood pressure was measured twice during the interview, using a unified electronic blood pressure monitor (Omron HEM-7430; Omron Corporation, Kyoto, Japan) and standardized procedures. 20 Antihypertensive medications. We focused on 62 oral medications by generic names listed in the database of the China Clinical Guideline for Hypertension Management 2010 regardless of whether they were recommended, 2,21 and the essential medicine lists.…”

Protocol for a nationwide survey of primary health care in China: the China PEACE (Patient-centered Evaluative Assessment of Cardiac Events) MPP (Million Persons Project) Primary Health Care Survey

“…The survey leverages the ongoing MPP study in China. 12 The MPP is a national population-based screening project across China to identify subjects aged from 35 to 75 years with high risk of CVD. All PHC institutions of the MPP network will be enrolled in the survey, including township hospital and village clinics in rural areas and community health centres and stations in urban areas (online supplementary appendix 2 describes the PHC institutions and their function in more detail).…”

“…The study was developed with funding from the National Development and Reform Commission of China and builds on an ongoing project, the China Patient-centered Evaluative Assessment of Cardiac Events (PEACE) Million Persons Project (MPP). 12 The China PEACE MPP is a nationwide population-based project aiming to identify subjects with high CVD risk and investigate their treatment, management, and outcomes. The collaborators of the MPP network include PHC institutions, secondary and tertiary hospitals, and Centers of Disease Control and Prevention (CDCs) across 31 provinces in mainland China.…”

The relationship between famine exposure in early life and ascending aorta dilatation in adulthood

“…The data used in the current study were obtained from the samples from the Early Screening and provinces in mainland China [13]. There were total of 10984 participants completed the screening in Guangdong province between 1 January 2017 and 31 December 2018.Among them aged 35 to 75 years and who completed the evaluation of the diameter of the ascending aorta (AAO) were included.…”