Protocol for emergency EPR dosimetry in fingernails

Trompier, F.; Kornak, L.; Calas, C.; Romanyukha, A.; LeBlanc, B.; Mitchell, C. A.; Swartz, Harold M.; Clairand, I.

doi:10.1016/j.radmeas.2007.05.024

Cited by 69 publications

(61 citation statements)

References 4 publications

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“…In order to reduce the MIS intensity, a procedure of short-time (5e10 min) soaking in water was suggested by Trompier et al (2007) and further developed in Reyes et al, 2008Reyes et al, , 2009 using a very small sample (2 mg). As it was discussed by Reyes et al (2008) soaking in water effectively eliminate MIS1, while MIS2 (stable mechanically-induced component) has a trend of slow increase with time after treatment.…”

Section: Resultsmentioning

confidence: 99%

“…Significant progress in the development of electron paramagnetic resonance (EPR) dosimetry in fingernails has been achieved in recent years (see Reyes et al, 2008Reyes et al, , 2009Romanyukha et al, 2007bRomanyukha et al, , 2010Trompier et al, 2007Trompier et al, , 2009. Chemically, fingernails are mainly composed of alpha keratin, a protein made of three alpha helical peptide chains, twisted in a left-handed coil that is strengthened by disulfide bridges from adjacent cystein groups.…”

Section: Introductionmentioning

confidence: 99%

“…These MISs obscure the RIS at low doses (<5 Gy). Water treatment of fingernails prior to dose measurements was first suggested by Trompier et al (2007) to reduce the MIS intensity. However, a persistent component is observed with similar spectral characteristics as RIS, which can induce an error in dose estimation.…”

Section: Introductionmentioning

confidence: 99%

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EPR measurements of fingernails in Q-band

Romanyukha¹,

Trompier

Reyes

et al. 2011

Radiation Measurements

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a b s t r a c tResults of a feasibility study for the use of the Q-band EPR measurements of fingernails are presented. Details of the first protocol developed for Q-band (34 GHz) EPR dose measurements in fingernails and preliminary results of a dosimetry study in comparison with the commonly-used X-band (9 GHz) are reported. It was found that 1e5 mg sample mass was sufficient for EPR measurements in fingernails in the Q-band, which is significantly less than the 15e30 mg needed for the X-band. This finding makes it possible to obtain sufficient fingernail sample for dose measurements, practically from every finger of any person. Another finding was that the spectral resolution of the mechanically-induced signal (MIS) and radiation-induced signal (RIS) in the Q-band was significantly better than in the X-band. The RIS and MIS in the Q-band spectrum have a more complex structure than in the X-band, which potentially offers the possibility to do dose measurements in fingernails without treatment and immediately after clipping. These findings and recent results related to fingernail dosimetry in the Q-band and its perspectives are discussed here.Published by Elsevier Ltd.

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Section: Resultsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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EPR measurements of fingernails in Q-band

Romanyukha¹,

Trompier

Reyes

et al. 2011

Radiation Measurements

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“…This research stems from previous studies to further justify the use of ESR as a dosimetric standard, much in the same fashion as Swartz et al proposed in their publications about the use of in vivo teeth EPR dosimetry during a terrorist event, accident or war involving ionizing radiation sources [30,31]. It offers specific recommendations for the evaluation parameters that would be most effective in producing the data needed for the development of an EPR dosimetry response protocol, in a similar fashion as that reported in Trompier et al and Alexander et al [32,33]. A protocol of this type can be used to evaluate radiation exposures right after a radiological/nuclear accident/incident and in retrospective dose studies, and can set the stage for the development of in vivo fingernail EPR dosimetry.…”

Section: Background and Significance Of Researchmentioning

confidence: 89%

Study of EPR/ESR Dosimetry in Fingernails as a Method for Assessing Dose of Victims of Radiological Accidents/Incidents

Reyes¹

2008

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The threat of nuclear terrorism and the potential for the use of radiation as a weapon make having an efficient and accurate radiation dosimetry methodology paramount. This study gives a physical/mechanical explanation to the behavior of EPR signals in fingernail dosimetry by modeling fingernails as sponges. Since previous work was performed using stressed (untreated) samples, they do not represent the realistic behavior of unstressed (treated) fingernails. The developed treatment eliminates the combined effect of the mechanical EPR signals, MIS1 (former MIS), and MIS2 (former BKS). As nail samples are physically restored with treatments, are not stressed, and display a response closer to that of in vivo specimens. The RIS is proportional to the radiation dose and shows a curvilinear dose response in unstressed samples using the additive dose method that can be modeled with a saturating exponential model (Grun model) for predicting residual or accidental radiological dose.Water content and mechanical stress were identified as the major factors affecting radiation sensitivity and its shape in fingernail EPR measurements respectively. It is proposed that treated samples be used in fingernail EPR dosimetry because they show more stable signals than untreated ones and have lower interpersonal and intrapersonal variability. Practical conditions of sample collection, preparation, and measurements at an accident site can be met with techniques illustrated in this study.v

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“…There is renewed interest in quantitation of these electron paramagnetic resonance (EPR) signals because of their potential utility for measuring radiation dose, especially for medical triage in situations where there is a need to determine whether large numbers of people were exposed to medically significant doses of radiation (3)(4)(5)(6)(7)(8)(9)(10)(11)(12)(13) . Fingernail dosimetry has been applied to three cases of accidental radiation exposure (14) .…”

Section: Introductionmentioning

confidence: 99%

Comparison of Continuous Wave and Rapid Scan X-band Electron Paramagnetic Resonance of Irradiated Clipped Fingernails

Elajaili

McPeak

Romanyukha³

et al. 2016

Radiat Prot Dosimetry

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X-band rapid scan electron paramagnetic resonance (EPR) measures the free radicals in irradiated clipped fingernails with higher signal-to-noise (S/N) and lower standard deviation of the signal amplitude for replicate measurements than does conventional continuous wave (CW) EPR in the same measurement time. For a clipped fingernail sample irradiated to 10 Gy and data acquisition time of 30 s with B 1 = 8.5 μT, the S/N for rapid scan is >2000 for the absorption spectrum and 1200 for the corresponding first derivative. The standard deviation for replicate measurements of signal amplitude is~1%. For CW spectra, the S/N depends on the modulation amplitude. The CW signal has a first derivative peak-to-peak linewidth of 0.95 mT. For 30 s of CW acquisition time, the S/N was 30 for a conservative modulation amplitude of 0.2 mT and B 1 of 2.3 μT or 90 for a modulation amplitude of 0.4 mT and B 1 of 3.2 μT, which resulted in standard deviations of replicate measurements of 5% or 2%, respectively.

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Protocol for emergency EPR dosimetry in fingernails

Cited by 69 publications

References 4 publications

EPR measurements of fingernails in Q-band

EPR measurements of fingernails in Q-band

Study of EPR/ESR Dosimetry in Fingernails as a Method for Assessing Dose of Victims of Radiological Accidents/Incidents

Comparison of Continuous Wave and Rapid Scan X-band Electron Paramagnetic Resonance of Irradiated Clipped Fingernails

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