Protocol for assessing auditory brainstem response in mice using a four-channel recording system

Zeng, Lingling; Zhou, Wen; Dai, Bing; Xie, Li; Wang, Xiaodi; Zhang, Guo

doi:10.1016/j.xpro.2022.101251

Cited by 2 publications

(2 citation statements)

References 14 publications

(18 reference statements)

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“…The results of direct electrical stimulation by BSEM are shown in Figure 4b and Figure S22 (Supporting Information) (different excitation intensities), which are similar to previous studies on human and animals. [ 30 , 31 , 32 ] The results show that the electric signal with different frequencies (300–5000 Hz) and intensities (80–90 dB) converted by BSEM could lead to ABR in mice. For comparison, the results of normal mice and deaf mice (bilateral tympanic membrane and ossicular chain destroyed) under acoustic stimulations are illustrated in Figure 4c .…”

Section: Resultsmentioning

confidence: 99%

Bioinspired Soft Elastic Metamaterials for Reconstruction of Natural Hearing

et al. 2023

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Natural hearing which means hearing naturally like normal people is critical for patients with hearing loss to participate in life. Cochlear implants have enabled numerous severe hearing loss patients to hear voice functionally, while cochlear implant users can hardly distinguish different tones or appreciate music subject to the absence of rate coding and insufficient frequency channels. Here a bioinspired soft elastic metamaterial that reproduces the shape and key functions of the human cochlea is reported. Inspired by human cochlea, the metamaterials are designed to possess graded microstructures with high effective refractive index distributed on a spiral shape to implement position‐related frequency demultiplexing, passive sound enhancements of 10 times, and high‐speed parallel processing of 168‐channel sound/piezoelectric signals. Besides, it is demonstrated that natural hearing artificial cochlea has fine frequency resolution up to 30 Hz, a wide audible range from 150–12 000 Hz, and a considerable output voltage that can activate the auditory pathway in mice. This work blazes a promising trail for reconstruction of natural hearing in patients with severe hearing loss.

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Section: Resultsmentioning

confidence: 99%

Bioinspired Soft Elastic Metamaterials for Reconstruction of Natural Hearing

et al. 2023

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“…However, manuscripts focused on detailed ABR protocols have also been published in peer-reviewed journals, and we list them in Table 4 below. Protocol for assessing auditory brainstem response in mice using a four-channel recording system 2022 mice [124] Auditory brainstem response (ABR) measurements in small mammals," in Developmental, Physiological, and Functional Neurobiology of the Inner Ear 2022 mice (suggested application also for rats, hamsters, and bats)…”

Section: Protocolsmentioning

confidence: 99%

Universal Recommendations on Planning and Performing the Auditory Brainstem Responses (ABR) with a Focus on Mice and Rats

Domarecka

Szczepek

2023

Audiology Research

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Translational audiology research aims to transfer basic research findings into practical clinical applications. While animal studies provide essential knowledge for translational research, there is an urgent need to improve the reproducibility of data derived from these studies. Sources of variability in animal research can be grouped into three areas: animal, equipment, and experimental. To increase standardization in animal research, we developed universal recommendations for designing and conducting studies using a standard audiological method: auditory brainstem response (ABR). The recommendations are domain-specific and are intended to guide the reader through the issues that are important when applying for ABR approval, preparing for, and conducting ABR experiments. Better experimental standardization, which is the goal of these guidelines, is expected to improve the understanding and interpretation of results, reduce the number of animals used in preclinical studies, and improve the translation of knowledge to the clinic.

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Protocol for assessing auditory brainstem response in mice using a four-channel recording system

Cited by 2 publications

References 14 publications

Bioinspired Soft Elastic Metamaterials for Reconstruction of Natural Hearing

Bioinspired Soft Elastic Metamaterials for Reconstruction of Natural Hearing

Universal Recommendations on Planning and Performing the Auditory Brainstem Responses (ABR) with a Focus on Mice and Rats

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