Protocol for a prospective, hospital-based registry of pregnant women with SARS-CoV-2 infection in India: PregCovid Registry study

Gajbhiye, Rahul; Mahajan, Niraj N.; Waghmare, Rakesh; Surve, Suchitra; Howal, Prashant V.; Bhurke, Aishwarya V.; Pious, Merlin; Modi, Deepak; Mahale, Smita D.

doi:10.1101/2021.07.21.21260823

Cited by 2 publications

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References 15 publications

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“…The data of women with COVID‐19 and PTB admitted to NH, Mumbai, India from April 4, 2020 to July 4, 2021 9 . Details of the PregCovid registry protocol and data collection methods are described elsewhere 10 . Data from 1630 pregnant and postpartum women with COVID‐19 were analyzed for this study.…”

Section: Methodsmentioning

confidence: 99%

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Increased spontaneous preterm births during the second wave of the coronavirus disease 2019 pandemic in India

Mahajan

Pednekar

Gaikwad

et al. 2021

Intl J Gynecology & Obste

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Objective To compare spontaneous preterm birth (SPTB) and iatrogenic preterm birth (IPTB) rates during both waves of the coronavirus disease 2019 (COVID‐19) pandemic. Methods Retrospective analysis of the PregCovid registry of pregnant women with COVID‐19 was performed at a dedicated COVID‐19 hospital in Mumbai, India. The data of 1630 women were analyzed for this study between April 4, 2020 and July 4, 2021. Prepandemic data were analyzed and compared with pandemic data. Main outcome measure was spontaneous preterm birth rate. Results Preterm deliveries were higher during the second wave (46/329; 14%) compared with the first wave (82/807; 10.2%) of the COVID‐19 pandemic (P = 0.065). Higher SPTBs were reported during the second wave than the first wave (12.5% versus 8.3%) (P = 0.03) as well as the prepandemic period (12.5% versus 10.5%) (P = 0.286). IPTBs were significantly lower in the pandemic period than in the prepandemic period (1.8 versus 3.3) (P = 0.012). Conclusion In Mumbai, India, we found an unusual change in SPTBs during the 6 months of the second wave of COVID‐19 compared with the previous 10 months of the first wave of pandemic and 1 year of prepandemic.

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Section: Methodsmentioning

confidence: 99%

“…9 Details of the PregCovid registry protocol and data collection methods are described elsewhere. 10 Data from 1630 pregnant and postpartum women with COVID-19 were analyzed for this study. PTB was defined as all births before 37 completed weeks of gestation.…”

Section: Materials S and Me Thodsmentioning

confidence: 99%

Increased spontaneous preterm births during the second wave of the coronavirus disease 2019 pandemic in India

Mahajan

Pednekar

Gaikwad

et al. 2021

Intl J Gynecology & Obste

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“…The data were captured as per the standardized data collection methods of the PregCovid registry. 7 A total of 2028 pregnant and post-partum women with COVID-19 were admitted during the rst, second, and third wave of COVID-19 at NH.…”

Section: Methodsmentioning

confidence: 99%

Clinical presentation, pregnancy complications and maternal outcomes of SARS-CoV-2 infection in pregnant women during the third wave of COVID-19 in Mumbai, India

Mahajan

Kesarwani

Salunke

et al. 2022

Preprint

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Importance: Following the outbreak of SARS-CoV-2 infection, it is unclear whether there is any difference in clinical presentation, disease severity, pregnancy complications, and maternal outcomes in pregnant and postpartum women during the third wave of COVID-19 as compared to the earlier two waves of COVID-19. Objective: To assess the clinical presentation, disease severity, pregnancy complications, and maternal outcomes in women affected with COVID-19 during the third wave in India and compare these parameters with the first wave and second wave of COVID-19.Design: Retrospective observational cohort study Setting: Tertiary care, dedicated COVID-19 hospital catering to Mumbai Metropolitan Region, India Participants: A total of 2,028 pregnant and postpartum women were admitted during three-wave periods: first wave - 1st April 2020 to 31st January 2021, second wave - 1st February 2021 to 10th December 2021; and third wave - 18th December 2021 to 19th January 2022. Exposures: SARS-CoV-2 infection in pregnant and post-partum women confirmed by laboratory confirmation of COVID-19 Main Outcomes and Measures: The primary outcome measures were disease severity, pregnancy complications, and maternal mortality during the third wave compared to the first and second waves of COVID-19. Results: A total of 2028 pregnant and postpartum women with COVID-19 diagnosis were enrolled during the first, second, and third waves of COVID-19. The hospitalization rate of pregnant and post-partum women with COVID-19 during the first four weeks of the third wave was higher than the earlier two waves as 288 women got admitted within 33 days. The number of SARS-CoV-2 infected pregnant and post-partum women with symptoms of COVID-19 were five times higher during the third wave as compared to the first wave (OR=5.1, 95% CI, 3.8-6.7, p<.001). On the contrary, there was a significantly lower proportion of pregnant and postpartum women with moderate to severe COVID-19 during the third wave (0.3%, 1/288) as compared to those during the first wave (2.4%, 27/1143, p<.001) and second wave (14.4%, 86/597) [p<.001]. The ICU/HDU admissions during the third wave were significantly lower (2.4%,7/288) than those during the second wave (14.7%,88/597) [OR =0.1, 95% CI, 0.1-0.3, p<.001] but similar to the first wave (2.4%,27/1143). No maternal deaths were reported during the third wave till 19th January 2022. Eclampsia was observed four times higher during the third wave as compared to the second wave (OR=4.1, 95 % CI, 0.8-22.6, p =.19) and first wave (OR=4.4, 95% CI, 0.9-12.7, p=.15). Conclusions and Relevance: Decreased severity of COVID-19 and reduced maternal mortality and morbidity were reported in the third wave as compared to the first wave and second wave of COVID-19 in the Mumbai Metropolitan Region, India.Trial Registration: The study is registered with the Clinical Trial Registry of India (Registration no: CTRI/2020/05/025423).

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Clinical characteristics, outcomes, & mortality in pregnant women with COVID-19 in Maharashtra, India: Results from PregCovid registry

et al. 2021

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Background & objectives : The PregCovid registry was established to document the clinical presentations, pregnancy outcomes and mortality of pregnant and post-partum women with COVID-19. Methods : The PregCovid registry prospectively collects information in near-real time on pregnant and post-partum women with a laboratory-confirmed diagnosis of SARS-CoV-2 from 19 medical colleges across the State of Maharashtra, India. Data of 4203 pregnant women collected during the first wave of the COVID-19 pandemic (March 2020-January 2021) was analyzed. Results : There were 3213 live births, 77 miscarriages and 834 undelivered pregnancies. The proportion of pregnancy/foetal loss including stillbirths was six per cent. Five hundred and thirty-four women (13%) were symptomatic, of which 382 (72%) had mild, 112 (21%) had moderate, and 40 (7.5%) had severe disease. The most common complication was preterm delivery (528, 16.3%) and hypertensive disorders in pregnancy (328, 10.1%). A total of 158 (3.8%) pregnant and post-partum women required intensive care, of which 152 (96%) were due to COVID-19 related complications. The overall case fatality rate (CFR) in pregnant and post-partum women with COVID-19 was 0.8 per cent (34/4203). Higher CFR was observed in Pune (9/853, 1.1%), Marathwada (4/351, 1.1%) regions as compared to Vidarbha (9/1155, 0.8%), Mumbai Metropolitan (11/1684, 0.7%), and Khandesh (1/160, 0.6%) regions. Comorbidities of anaemia, tuberculosis and diabetes mellitus were associated with maternal deaths. Interpretation & conclusions : The study demonstrates the adverse outcomes including severe COVID-19 disease, pregnancy loss and maternal death in women with COVID-19 in Maharashtra, India.

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Protocol for a prospective, hospital-based registry of pregnant women with SARS-CoV-2 infection in India: PregCovid Registry study

Cited by 2 publications

References 15 publications

Increased spontaneous preterm births during the second wave of the coronavirus disease 2019 pandemic in India

Increased spontaneous preterm births during the second wave of the coronavirus disease 2019 pandemic in India

Clinical presentation, pregnancy complications and maternal outcomes of SARS-CoV-2 infection in pregnant women during the third wave of COVID-19 in Mumbai, India

Clinical characteristics, outcomes, & mortality in pregnant women with COVID-19 in Maharashtra, India: Results from PregCovid registry

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