Protocol for a multicentre, prospective observational study of elective neck dissection for clinically node-negative oral tongue squamous cell carcinoma (END-TC study)

Yanamoto, Souichi; Michi, Yasuyuki; Otsuru, Mitsunobu; Inomata, Toru; Nakayama, Hideki; Nomura, Takeshi; Hasegawa, Takumi; Yamamura, Yukio; Yamada, Shin‐ichi; Kusukawa, Jingo; Yamakawa, Nobuhiro; Hasegawa, On; Kitagawa, Yoshimasa; Hiraki, Akimitsu; Hasegawa, Takuya; Ohiro, Yoichi; Kobayashi, Wataru; Asoda, Seiji; Kobayashi, Takanori; Iino, Mitsuyoshi; Fukuda, Masayuki; Ishibashi‐Kanno, Naomi; Kawaguchi, Koji; Aijima, Reona; Noguchi, Kazuma; Okura, Masaya; Tanaka, Akira; Sugiura, Tetsuro; Shintani, Yukari; Yagihara, Kazuhiro; Yamashiro, Masashi; Ota, Yoshihide; Miyazaki, Akira; Takeshita, Akinori; Kawamata, Hitoshi; Hiroshi, Iwabuchi; Uchida, Kenichiro; Umeda, Masahiro; Kitamura, Hiroshi; Kirita, Tadaaki

doi:10.1136/bmjopen-2021-059615

Cited by 3 publications

(1 citation statement)

References 16 publications

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“…A prospective observational study of prophylactic neck dissection for cN0 cancers (END-TC Study: UMIN000027875) [50] is currently underway in Japan, and together with a randomized phase III study (RESPOND: JCOG1601) [51] comparing partial tongue resection plus neck dissection with partial tongue resection alone for stage I/II tongue cancer, the criteria for the prognostic predictors of END and their usefulness will be clarified.…”

Section: Discussionmentioning

confidence: 99%

A Study of the Prognostic Factors for Late Cervical Lymph Node Metastasis and Distant Metastasis in Patients with cT1-2N0 Tongue Cancer

Obayashi,

Koizumi,

Ito

et al. 2024

JCM

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Background: Early-stage tongue cancer has a good prognosis in general; however, high-risk patients with late cervical lymph node and distant metastases have a poor prognosis. Elective neck dissection and postoperative chemoradiotherapy are considered for these patients, although no clear criteria have been identified for their evaluation. Methods: This retrospective observational study aimed to determine the predictive factors for late cervical lymph node and distant metastases in 102 patients with cT1-2N0 tongue cancer. The data regarding the demographic characteristics, as well as the depth of invasion, tumor budding, histological grade, and tumor–stromal ratio, among other things, were extracted from medical records. Results: We found that the potential lymph node metastasis rate was 27.5%. The significant clinical predictors of late cervical lymph node metastasis were the tumor thickness and endophytic growth pattern and the significant histopathological factors were poorly and moderately differentiated tumors and ≥3 tumor buds. In addition, the prognostic factors for distant metastasis included ≥4 lymph node metastases, ≥7 tumor budding, and moderate and poor tumor differentiation. Conclusions: The usefulness of tumor budding as a predictor of metastasis for tongue cancer was suggested. The findings of this study can help establish the criteria for evaluating the metastasis risk and prognosis of patients with tongue cancers.

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Section: Discussionmentioning

confidence: 99%

A Study of the Prognostic Factors for Late Cervical Lymph Node Metastasis and Distant Metastasis in Patients with cT1-2N0 Tongue Cancer

Obayashi,

Koizumi,

Ito

et al. 2024

JCM

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Historical milestones in the evolution of the procedure of neck dissection

Devaraja

2024

World j. otorhinolaryngol.-head neck surg.

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ObjectiveAlthough neck dissection has evolved to become an integral part of the surgical armamentarium for managing head and neck cancers, the manner in which the procedure has reached its present state is worth revisiting.Data SourcesPublished original articles, reviews, clinical practice guidelines, and consensus statements related to the basis, indication, and classification of the neck dissection.MethodsThis review discusses some of the critical milestones before and after the description of the procedure of neck dissection by George Crile Sr. in 1905, which eventually played a role in the evolution of this commonly performed oncosurgical procedure.ResultsSeveral large observational studies of the twentieth century and multicentric randomized trials at the turn of the twenty‐first century have shaped neck dissection into a safe and reliable oncosurgical procedure.ConclusionsFrom being a radical surgery that was done mostly in large nodal diseases for curative or palliative purposes to becoming a simple procedure that is carried out even in node‐negative cases of head and neck cancers for prognostic purposes, the procedure of neck dissection has come a long way and continues to evolve.

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cN0舌癌における予防的頸部郭清術の有効性

Yanamoto,

Umeda,

Kurita

et al. 2023

Journal of Japan Society for Oral Tumors

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Oral cancer is a rare cancer that accounts for 1％ of all cancers, or about 6 per 100,000 people. In 2014, the Japanese Ministry of Health, Labour, and Welfare (MHLW) created the "10-Year Strategy for Cancer Research" and designated "oral cancer" as a priority research area as a rare cancer that is difficult to study. Since there are limitations in conducting high-quality clinical research at individual institutions, multi-institutional research is becoming increasingly important. The Japanese Society of Oral Oncology has established a joint research committee, and various studies are being conducted. This study is a prospective, multi-institutional, non-randomized observational study. The choice of whether to perform elective neck dissection (END) for clinically node-negative (cN0) oral tongue squamous cell carcinoma (OTSCC) at the same time as resection of the primary tumor is based on institutional policy and patient preference. The primary endpoint of this study is 3-year overall survival. The secondary endpoints are 3-year diseasespecific survival, 3-year relapse-free survival, and the impact on patient quality of life (QoL) . The impact of QoL is assessed by using the Functional Assessment of Cancer Therapy-Head and Neck (Version 4 ; FACT-H&N) and the Disabilities of the Arm, Shoulder, and Hand (DASH) questionnaire. Confounding factors will be adjusted to reduce selection bias. The results of this study may provide new outcome-oriented insights into the efficacy of END for cN0 OTSCC in terms of patient QoL in Japan.

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Protocol for a multicentre, prospective observational study of elective neck dissection for clinically node-negative oral tongue squamous cell carcinoma (END-TC study)

Cited by 3 publications

References 16 publications

A Study of the Prognostic Factors for Late Cervical Lymph Node Metastasis and Distant Metastasis in Patients with cT1-2N0 Tongue Cancer

A Study of the Prognostic Factors for Late Cervical Lymph Node Metastasis and Distant Metastasis in Patients with cT1-2N0 Tongue Cancer

Historical milestones in the evolution of the procedure of neck dissection

cN0舌癌における予防的頸部郭清術の有効性

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