Protocatechuic acid activates key components of insulin signaling pathway mimicking insulin activity

Abstract

This study showed that PCA stimulates the insulin signaling pathway in human adipocytes increasing GLUT4 translocation and glucose uptake. Decreasing insulin resistance is a most desirable aim to be reached for an effective therapeutic/preventive action against metabolic syndrome and type 2 diabetes. Identifying specific food/food components able to improve glucose metabolism can offer an attractive, novel, and economical strategy.

Alleviating VLDL overproduction is an important mechanism for Laminaria japonica polysaccharide to inhibit atherosclerosis in LDLr−/− mice with diet‐induced insulin resistance

“…Actually, serine-302 phosphorylation of IRS-1 is reported to be an obvious indicator of IR and its enhancement often occurred in hepatic IR, as we have shown in the present study ( Fig. 6A and G) [39]. However, the long-term administration of LJP61A ameliorated IR by reducing serine-302 phosphorylation of IRS-1 in LDLr −/− mice fed HFD (Fig.…”

Berries and anthocyanins: promising functional food ingredients with postprandial glycaemia-lowering effects

“…Significant circulating metabolites include PCA and its metabolites vanillic and hippuric acid, as well as phloroglucinaldehyde and its metabolite ferulic acid (69,100) . In fact, some of these metabolites have been shown to be important for glucose uptake, insulin signalling and adipokine expression in in vitro studies in human and rat adipocytes (101)(102)(103) . Diabetic KK-A y mice subjected to 5-week daily administration of concentrated bilberry extract (27 g/kg diet) showed a marked reduction in fasting plasma glucose and improved insulin sensitivity (104) .…”

Effect of oil palm phenolics on gastrointestinal transit, contractility and motility in the rat

“…activates key components of insulin signalling pathways (Scazzocchio et al, 2015) and is protective of ischaemia/ reperfusion induced injuries of the rat heart (Tang et al, 2014) and mouse intestine (Ma et al, 2014). There is little information on the health effects of ρ-hydroxybenzoic acid other than the role of their alkyl esters, or parabens, which have been depicted as having androgen antagonist-type activity (Darbre & Harvey, 2008).…”