“…It is, therefore, possible that the interaction of Fz with ADAM13 is important in order to protect PAPC from degradation during internalization. It should be noted that Wnt11, Fz4, Fz7, PAPC and ADAM13 are all expressed in the CNC cells during migration (Alfandari et al, 1997;De Calisto et al, 2005;Matthews et al, 2008;Schneider et al, 2014;Swain et al, 2005). Furthermore, ADAM13 is also regulated by one of the kinases GSK3 that control the Wnt pathway.…”