Protoberberine alkaloids from Coscinium fenestratum

Pinho, Paulo; Pinto, Madalena; Kijjoa, Anake; Pharadai, Kalaya; Dı́az, Jesús; Herz, Werner

doi:10.1016/0031-9422(92)80301-t

Cited by 65 publications

(58 citation statements)

References 11 publications

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“…Though there is no report on the antiproliferative activity of Co. fenestratum, which shows selective activity against lung-related tumor cells, its constituents, benzylisoquinolinetype alkaloids such as berberine, 28,34) were reported to be cytotoxic. 35) The antiproliferative constituents of Cae.…”

Section: Resultsmentioning

confidence: 99%

Antiproliferative Activity of Vietnamese Medicinal Plants.

Ueda

Tezuka

Banskota

et al. 2002

Biological & Pharmaceutical Bulletin

131

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Section: Resultsmentioning

confidence: 99%

Antiproliferative Activity of Vietnamese Medicinal Plants.

Ueda

Tezuka

Banskota

et al. 2002

Biological & Pharmaceutical Bulletin

131

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“…Specifically, C. fenestratum is a widely used medicinal plant in Southeast asia (27). the major constituents of the stem are protoberberine alkaloids such as berberine, palmatine and jatrorrhizine (26,(28)(29)(30). in folkloric medicine, people favor the use of the stems and roots of C. fenestratum rather than the leaves due to their greater alkaloid content.…”

Section: Discussionmentioning

confidence: 99%

In vitro anti-proliferative activity of alcoholic stem extract of Coscinium fenestratum in human colorectal cancer cells

Rojsanga

Sukhthankar²,

Krisanapun³

et al. 2010

Experimental and Therapeutic Medicine

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Abstract. Coscinium fenestratum (Gaertn.) colebr. is traditionally used for the treatment of cancer, arthritis and diabetes mellitus. the purpose of this study was to determine the molecular mechanisms by which this plant shows beneficial effects. an 80% ethanolic extract of C. fenestratum (80et) was separated by its polarity into dichloromethane (dcm) and aqueous fractions (WF), and the anti-proliferative effects of 80et, dcm and WF were investigated. Berberine, one of the major components of C. fenestratum, was used as a control. the 80et, dcm, WF and berberine showed anti-proliferative activity as assessed by cell growth assay. Subsequently, the pro-apoptotic proteins naG-1 and atF3 were increased and the cell cycle protein cyclin d1 was decreased by the extract and its fractions. interestingly, only the dcm fraction exhibited the induction of peroxisome proliferator-activated receptor γ (pparγ) binding activity, which represents a pro-apoptotic activity in colorectal cancer cells. the overall results of this study indicate that the extract from this plant has anti-proliferative activity through the activation of pro-apoptotic proteins and pparγ, and may have potential as a preventive regimen in the treatment of cancer.

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“…The known compounds were identified as dauricumine (2) sinomenine N-oxide (10), 6 isosinomenine (11), 27 salutaridine (12), 28 8-oxoisocorypalmine (13), 29 and N-trans-feruloylmethoxytyramine (14), 21 by comparison of physicochemical and spectroscopic data with previously reported literature values. Extraction and Isolation.…”

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confidence: 99%