Prothrombin induced by vitamin K Absence-II versus alpha-fetoprotein in detection of both resectable hepatocellular carcinoma and early recurrence after curative liver resection: A retrospective cohort study

Wang, Mingda; Yang, Tian; Qian, Guojun; Li, Chao; Gu, Li-Hui; Yao, Lan-Qing; Diao, Yong-Kang; Pawlik, Timothy M.; Lau, Wan Yee; Huang, Dongsheng; Shen, Feng; Yang, Tian

doi:10.1016/j.ijsu.2022.106843

Cited by 27 publications

(30 citation statements)

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“…Recently, Wang et.al discovered positive preoperative PIVKA-II was an independent risk factor for postoperative recurrence of HCC within 2 years. 24 In this study, at the high positive detection background of PIVKA-II, the advantage of PIVKA-II in predicting tumor recurrence was compromised. By contrast, the ABH value has demonstrated similar sensitivity and remarkably superior specificity in our study.…”

Section: Discussionmentioning

confidence: 76%

“…The difference between our result and Wang's findings may lie in a high proportion of late-stage HCC from our study, while 82% of Wang's cohort is BCLC 0-A HCC patients. 24 PIVKA-II is mostly recognized as a sensitive indicator for early HCC 33 and modification of the cutoff value may be required to better predict postoperative recurrence in late HCC. To compare the prediction effectiveness between ABH and PIVKA-II, we detected the relation between paracancerous ABH value and the preoperational PIVKA-II (Figure 4D,E).…”

Section: Discussionmentioning

confidence: 99%

“…Interestingly, we found a series of regulations of the expression of E2F7 and Anillin with the abundance of binuclear hepatocytes (ABH) in the paracancerous liver tissues close to the tumor margin within 1 cm. The increase of E2F7 and Anillin presented to be negatively correlated with ABH value, and the preoperative level of protein induced by vitamin K absence or antagonist‐II (PIVKA‐II), which has been reported as an independent risk factor of HCC recurrence, 24 showed a significant correlation with the changes in ABH. Moreover, we found that ABH value changes provided much more specificity for short‐term recurrence in HCC.…”

Section: Introductionmentioning

confidence: 90%

“…3.5 | Attenuation of ABH is more specific in predicting HCC short-term recurrence than PIVKA-II PIVKA-II is a recently recognized serum HCC-specific biomarker. Since positive PIVKA-II was reported to indicate poor prognosis and recurrence, 24 we also examined the relationship between PIVKA-II and short-term recurrence. Indeed, PIVKA-II was detected in most of HCC patients (71.83%, 102/142).…”

Section: Attenuation Of Abh In the Paracancerous Liver Is An Indicato...mentioning

confidence: 99%

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Attenuation of binuclear hepatocytes in the paracancerous liver tissue is associated with short‐term recurrence of hepatocellular carcinoma post‐radical surgery

Zhang,

Wang,

Hao

et al. 2023

The FASEB Journal

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Short‐term recurrence of hepatocellular carcinoma (HCC) after radical resection leads to dismal outcomes. To screen high‐recurrence risk patients to provide adjuvant treatment is necessary. Herein, based on our previous research, we further focused on the changes in the abundance of binuclear hepatocytes (ABH) in the paracancerous liver tissue to discuss the relationship between the attenuation of binuclear hepatocytes and postoperative short‐term recurrence, by combining with the assessment of the value of a reported independent early recurrence risk factor in HCC, protein induced by vitamin K absence or antagonist‐II (PIVKA‐II). A cohort of 142 paracancerous liver tissues from HCC patients who received radical resection was collected. Binuclear hepatocytes were reduced in the paracancerous liver tissues, compared with the liver tissues from normal donors. ABH was negatively correlated with clinical features such as tumor size, TNM stages, tumor microsatellite formation, venous invasion, and Alpha‐fetoprotein (AFP) level, as well as the expression of E2F7 and Anillin, which are two critical regulators concerning the hepatocyte polyploidization. According to the short‐term recurrence information, ABH value was laminated, and univariate and multivariate logistic regression was performed to analyze the relationship between paracancerous ABH and short‐term tumor relapse. Simultaneously, the predictive effectiveness of the ABH value was compared with the preoperative PIVKA‐II value. As observed, the paracancerous ABH value below 1.5% was found to be an independent risk factor for recurrence. In conclusion, the paracancerous ABH is a credible indicator of short‐term recurrence of HCC patients after radical resection, and regular assessment of ABH might help to prevent short‐term HCC recurrence.

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Section: Discussionmentioning

confidence: 76%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 90%

Section: Attenuation Of Abh In the Paracancerous Liver Is An Indicato...mentioning

confidence: 99%

See 2 more Smart Citations

Attenuation of binuclear hepatocytes in the paracancerous liver tissue is associated with short‐term recurrence of hepatocellular carcinoma post‐radical surgery

Zhang,

Wang,

Hao

et al. 2023

The FASEB Journal

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“…Alpha fetoprotein (AFP), interleukin-6 (IL-6) and tumor necrosis factoralpha (TNF-ɑ) have been found to be related to HCC treatment outcomes (212)(213)(214). A recent study indicated that preoperative prothrombin induced by vitamin K absence-II (PIVKA-II) has a higher positive rate than AFP in detecting resectable HCC and predicting early postoperative recurrence (215). The level of PIVKA-II can serve as an indicator of the presence of PVTT and an advanced tumor stage (216).…”

Section: Molecular Biomarkersmentioning

confidence: 99%

An overview: Management of patients with advanced hepatocellular carcinoma

Wang

Sun

et al. 2022

BST

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PIVKA‐II combined with tumor burden score to predict long‐term outcomes of AFP‐negative hepatocellular carcinoma patients after liver resection

Qiu,

Wu,

et al. 2023

Cancer Medicine

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BackgroundThis study aimed to establish a simple prognostic scoring model based on tumor burden score (TBS) and PIVKA‐II to predict long‐term outcomes of α‐fetoprotein (AFP)‐negative hepatocellular carcinoma (HCC) patients.Methods511 patients were divided into the training cohort (n = 305) and the validation cohort (n = 206) at a ratio of 6:4. Receiver operating characteristic curves (ROC) were established to identify cutoff values of TBS and PIVKA‐II. Kaplan–Meier curves were used to analyze survival outcomes. The multivariable Cox regression was used to identify variables independently associated with survival outcomes. The predictive performance of the TBS‐PIVKA II score (TPS) model was compared with Barcelona clinic liver cancer (BCLC) stage and American Joint Committee on Cancer (AJCC TNM) stage.ResultsThe present study established the TPS model using a simple scoring system (0, 1 for low/high TBS [cutoff value: 4.1]; 0, 1 for low/high PIVKA‐II [cutoff value: 239 mAU/mL]). The TPS scoring model was divided into three levels according to the summation of TBS score and PIVKA‐II score: TPS 0, TPS 1, and TPS 2. The TPS scoring model was able to stratify OS (training: p < 0.001, validation: p < 0.001) and early recurrence (training: p < 0.001; validation: p = 0.001) in the training cohort and the validation cohort. The TPS score was independently associated with OS (TPS 1 vs. 0, HR: 2.28, 95% CI: 1.01–5.17; TPS 2 vs. 0, HR: 4.21, 95% CI: 2.01–8.84) and early recurrence (TPS 1 vs. 0, HR: 3.50, 95% CI: 1.71–7.16; TPS 2 vs. 0, HR: 3.79, 95% CI: 1.86–7.75) in the training cohort. The TPS scoring model outperformed BCLC stage and AJCC TNM stage in predicting OS and early recurrence in the training cohort and the validation cohort. But the TPS scoring model was unable to stratify the late recurrence in the training cohort (p = 0.872) and the validation cohort (p = 0.458).ConclusionsThe TPS model outperformed the BCLC stage and AJCC TNM stage in predicting OS and early recurrence of AFP‐negative HCC patients after liver resection, which might better assist surgeons in screening AFP‐negative HCC patients who may benefit from liver resection.

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Prothrombin induced by vitamin K Absence-II versus alpha-fetoprotein in detection of both resectable hepatocellular carcinoma and early recurrence after curative liver resection: A retrospective cohort study

Cited by 27 publications

References 32 publications

Attenuation of binuclear hepatocytes in the paracancerous liver tissue is associated with short‐term recurrence of hepatocellular carcinoma post‐radical surgery

Attenuation of binuclear hepatocytes in the paracancerous liver tissue is associated with short‐term recurrence of hepatocellular carcinoma post‐radical surgery

An overview: Management of patients with advanced hepatocellular carcinoma

PIVKA‐II combined with tumor burden score to predict long‐term outcomes of AFP‐negative hepatocellular carcinoma patients after liver resection

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