Abstract:Accumulated evidences confirmed that amyloid-β (Aβ) deposition, tau phosphorylation, acetylcholine decrease, etc, all contributed to the pathogenesis of Alzheimer's disease (AD). However, the underlying mechanism remains unclear, and novel AD biomarkers are urgently needed to be discovered. Herein, APP/PS1 double transgenic mice (AD mice) were employed, and the differentially expressed (DE) proteins of mice hippocampus were identified and analyzed by 4D label Free quantitative proteomics technology and paralle… Show more
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