Proteomics profiling of ertapenem challenged major porin deficient carbapenem-resistant Klebsiella pneumoniae

Yuan, Peibo; Ling, Jia-Hui; Zhu, Jia-Hui; Chen, Peng; Chen, En-Zhong; Zhong, Yu-Xia; Liu, Wan-Ting; Wang, Linjing; Yang, Ling; Chen, Dingqiang

doi:10.1016/j.jprot.2022.104715

Cited by 3 publications

(4 citation statements)

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“…Studies demonstrate that antibiotics can induce epigenetic changes in bacterial resistance, indicating the role of epigenetics ( Motta et al., 2015 ). While much research has focused on classical AMR mechanisms, these mechanisms fall short in explaining the emergence and spread of drug resistance due to factors such as bacterial adaptive evolution, heterogeneity, and late retention ( Depardieu et al., 2007 ; Depardieu et al., 2007 ; Zhang, 2014 ; Becker et al., 2018 ; Nolivos et al., 2019 ; Lv et al., 2021 ; Yuan et al., 2022 ). Therefore, epigenetics may provide useful answers to these questions.…”

Section: Introductionmentioning

confidence: 99%

“…Conjuction is the direct transfer of DNA molecules (such as plasmids) from donor bacteria to recipient bacteria through the pipeline formed by sex pilus. Transduction is the transfer of DNA from donor bacteria to recipient bacteria by bacteriophages ( Depardieu et al., 2007 ; Zhang, 2014 ; Yuan et al., 2022 ). Membrane vesicle fusion means that vesicles secreted which includes nucleic acids, enzymes and drug resistance genes and other substances, can enter another bacteria or host cells through direct fusion with host cell membrane or endocytosis ( Depardieu et al., 2007 ; Zhang, 2014 ; Yuan et al., 2022 ).…”

Section: Introductionmentioning

confidence: 99%

“…Transduction is the transfer of DNA from donor bacteria to recipient bacteria by bacteriophages ( Depardieu et al., 2007 ; Zhang, 2014 ; Yuan et al., 2022 ). Membrane vesicle fusion means that vesicles secreted which includes nucleic acids, enzymes and drug resistance genes and other substances, can enter another bacteria or host cells through direct fusion with host cell membrane or endocytosis ( Depardieu et al., 2007 ; Zhang, 2014 ; Yuan et al., 2022 ). The outer membrane porin mediates the entry and exit of antibiotics into and out of bacteria as a permeability barrier.…”

Section: Introductionmentioning

confidence: 99%

“…The production of antibiotic hydrolases, inactivating enzymes and modifying enzymes can lead to the inactivation of antibiotics. The mutation or modification of related targets makes it impossible for antibiotics to bind to the corresponding sites to play a bactericidal or bacteriostatic role ( Depardieu et al., 2007 ; Zhang, 2014 ; Yuan et al., 2022 ).…”

Section: Introductionmentioning

confidence: 99%

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Antimicrobial resistance and mechanisms of epigenetic regulation

Wang

2023

Front. Cell. Infect. Microbiol.

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The rampant use of antibiotics in animal husbandry, farming and clinical disease treatment has led to a significant issue with pathogen resistance worldwide over the past decades. The classical mechanisms of resistance typically investigate antimicrobial resistance resulting from natural resistance, mutation, gene transfer and other processes. However, the emergence and development of bacterial resistance cannot be fully explained from a genetic and biochemical standpoint. Evolution necessitates phenotypic variation, selection, and inheritance. There are indications that epigenetic modifications also play a role in antimicrobial resistance. This review will specifically focus on the effects of DNA modification, histone modification, rRNA methylation and the regulation of non-coding RNAs expression on antimicrobial resistance. In particular, we highlight critical work that how DNA methyltransferases and non-coding RNAs act as transcriptional regulators that allow bacteria to rapidly adapt to environmental changes and control their gene expressions to resist antibiotic stress. Additionally, it will delve into how Nucleolar-associated proteins in bacteria perform histone functions akin to eukaryotes. Epigenetics, a non-classical regulatory mechanism of bacterial resistance, may offer new avenues for antibiotic target selection and the development of novel antibiotics.

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