Proteomics in farm animals models of human diseases

Ceciliani, Fabrizio; Restelli, Liliana; Lecchi, Cristina

doi:10.1002/prca.201300080

Cited by 14 publications

(10 citation statements)

References 98 publications

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“…Finally, the continued development of novel proteomic approaches such as Capillary Electrophoresis-Mass Spectrometry (CE-MS) have the capability to identify panels of peptides that can be used for disease diagnosis and for differential diagnosis of the causative bacteria of the infections of the mammary gland (Mansor et al , 2013 ; Albalat et al , 2014 ). As with bovine species, a significant amount of proteomic studies have been performed on porcine species (de Almeida and Bendixen, 2012 ; Ceciliani et al , 2014 ). In addition to its role during meat production, the porcine species is an important animal model for the study of disease in humans.…”

Section: Proteomics In Farm Animals During Production In Health and Dmentioning

confidence: 99%

Animal board invited review: advances in proteomics for animal and food sciences

Almeida

Bassols

Bendixen

et al. 2015

Animal

136

119

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Animal production and health (APH) is an important sector in the world economy, representing a large proportion of the budget of all member states in the European Union and in other continents. APH is a highly competitive sector with a strong emphasis on innovation and, albeit with country to country variations, on scientific research. Proteomics (the study of all proteins present in a given tissue or fluid – i.e. the proteome) has an enormous potential when applied to APH. Nevertheless, for a variety of reasons and in contrast to disciplines such as plant sciences or human biomedicine, such potential is only now being tapped. To counter such limited usage, 6 years ago we created a consortium dedicated to the applications of Proteomics to APH, specifically in the form of a Cooperation in Science and Technology (COST) Action, termed FA1002 – Proteomics in Farm Animals: . In 4 years, the consortium quickly enlarged to a total of 31 countries in Europe, as well as Israel, Argentina, Australia and New Zealand. This article has a triple purpose. First, we aim to provide clear examples on the applications and benefits of the use of proteomics in all aspects related to APH. Second, we provide insights and possibilities on the new trends and objectives for APH proteomics applications and technologies for the years to come. Finally, we provide an overview and balance of the major activities and accomplishments of the COST Action on Farm Animal Proteomics. These include activities such as the organization of seminars, workshops and major scientific conferences, organization of summer schools, financing Short-Term Scientific Missions (STSMs) and the generation of scientific literature. Overall, the Action has attained all of the proposed objectives and has made considerable difference by putting proteomics on the global map for animal and veterinary researchers in general and by contributing significantly to reduce the East–West and North–South gaps existing in the European farm animal research. Future activities of significance in the field of scientific research, involving members of the action, as well as others, will likely be established in the future.

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Section: Proteomics In Farm Animals During Production In Health and Dmentioning

confidence: 99%

Animal board invited review: advances in proteomics for animal and food sciences

Almeida

Bassols

Bendixen

et al. 2015

Animal

136

119

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“…As a model organism, the pig is still a newcomer, partly because the pig genome was just recently published , but the diversity of available pig models is rapidly expanding. In particular for research in nutrition, inflammation, and host–microbial crosstalk, pig models present unmatched modeling opportunities , because the pig, like human, is an omnivore, with very similar nutritional requirements, digestive and immune systems, and gut microbial components. Current nutrigenomic research aims to characterize complex relational networks across animal genomics, nutrition, and gut microbes (metagenomics), which impact health, growth, and metabolism of the individual animal.…”

Section: Introductionmentioning

confidence: 99%

The Pig PeptideAtlas: A resource for systems biology in animal production and biomedicine

et al. 2016

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Biological research of Sus scrofa, the domestic pig, is of immediate relevance for food production sciences, and for developing pig as a model organism for human biomedical research. Publicly available data repositories play a fundamental role for all biological sciences, and protein data repositories are in particular essential for the successful development of new proteomic methods. Cumulative proteome data repositories, including the PeptideAtlas, provide the means for targeted proteomics, system wide observations, and cross species observational studies, but pigs have so far been underrepresented in existing repositories. We here present a significantly improved build of the Pig PeptideAtlas, which includes pig proteome data from 25 tissues and three body fluid types mapped to 7139 canonical proteins. The content of the Pig PeptideAtlas reflects actively ongoing research within the veterinary proteomics domain, and this manuscript demonstrates how the expression of isoform-unique peptides can be observed across distinct tissues and body fluids. The Pig PeptideAtlas is a unique resource for use in animal proteome research, particularly biomarker discovery and for preliminary design of SRM assays, which are equally important for progress in research that supports farm animal production and veterinary health, as for developing pig models with relevance to human health research.

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“…Understanding the pathophysiology: beside transcriptomics, proteomics applied to adipose tissue, for example, has evidently contributed to a huge advancement in the knowledge of the involvement of this tissue in the development of transition-related diseases [127]. Proteome maps have been established for several biological fluids and tissues in cattle [128], and the amount of the literature available on cow proteomics and metabolomics is steadily growing, as shown in Fig. 6.…”

Section: Proteomics and Metabolomics In Transition Period Related Dismentioning

confidence: 99%

Proteomics and metabolomics characterizing the pathophysiology of adaptive reactions to the metabolic challenges during the transition from late pregnancy to early lactation in dairy cows

Ceciliani

Lecchi

Urh

et al. 2018

Journal of Proteomics

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For high-yielding dairy cows there are several "occupational diseases" that occur mainly during the metabolic challenges related to the transition from pregnancy to lactation. Such diseases and their sequelae form a major concern for dairy production, and often lead to early culling of animals. Beside the economical perspective, metabolic stress may severely influence animal welfare. There is a multitude of studies about the metabolic backgrounds of such so called production diseases like ketosis, fatty liver, or hypocalcaemia, although the investigations aiming to assess the complexity of the pathophysiological reactions are largely focused on gene expression, i.e. transcriptomics. For extending the knowledge towards the proteome and the metabolome, the respective technologies are of increasing importance and can provide an overall view of how dairy cows react to metabolic stress, which is needed for an in-depth understanding of the molecular mechanisms of the related diseases. We herein review the current findings from studies applying proteomics and metabolomics to transition-related diseases, including fatty liver, ketosis, endometritis, hypocalcaemia and laminitis. For each disease, a brief overview of the up to date knowledge about its pathogenesis is provided, followed by an insight into the most recent achievements on the proteome and metabolome of tissues and biological fluids, such as blood serum and urine, highlighting potential biomarkers. We believe that this review would help readers to be become more familiar with the recent progresses of molecular background of transition-related diseases thus encouraging research in this field.

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Proteomics in farm animals models of human diseases

Cited by 14 publications

References 98 publications

Animal board invited review: advances in proteomics for animal and food sciences

Animal board invited review: advances in proteomics for animal and food sciences

The Pig PeptideAtlas: A resource for systems biology in animal production and biomedicine

Proteomics and metabolomics characterizing the pathophysiology of adaptive reactions to the metabolic challenges during the transition from late pregnancy to early lactation in dairy cows

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