Proteomics identified nuclear N-myc downstream-regulated gene 1 as a prognostic tissue biomarker candidate in renal cell carcinoma

Hosoya, N; Sakumoto, Marimu; Nakamura, Yukiko; Narisawa, Takafumi; Bilim, Vladimir; Motoyama, Teiichi; Tomita, Yoshihiko; Kondo, Tadashi

doi:10.1016/j.bbapap.2013.08.009

Cited by 30 publications

(25 citation statements)

References 39 publications

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“…Renal cell carcinoma (RCC) is the second most frequent urologic malignancy after bladder and is one of the most aggressive urologic malignancies, with a median survival of only 13 months. 1,2 The metastasis rate in RCC is 20% to 30% at the time of diagnosis, and 20% to 50% of patients with localized disease may show metastasis after nephrectomy. 3 The most important prognostic factors after surgery are TNM (Tumor-Node-Metastasis) staging and Fuhrman grade.…”

Section: Introductionmentioning

confidence: 99%

Monosomy of Chromosome 9 Is Associated With Higher Grade, Advanced Stage, and Adverse Outcome in Clear-cell Renal Cell Carcinoma

Nejati

Wei

Uzzo

et al. 2020

Clinical Genitourinary Cancer

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The objective of the study was to evaluate the frequency and the outcomes of whole chromosome 9 loss in 103 patients with clear-cell renal cell carcinoma (ccRCC) using single nucleotide polymorphism-based chromosome microarray analysis. Our study demonstrated that chromosome 9 loss is associated with higher grade, advanced stage, and poor outcome in ccRCC and can potentially be used as a major prognostic predictor in patients with ccRCC. Background: Clear-cell renal cell carcinoma (ccRCC) is one of the most common malignancies in humans and is usually associated with poor outcomes. Cancers are considered to be genetic diseases. Therefore, a better understanding of genetic alterations that are related to disease progression or poor prognosis can help to more precisely identify high-risk patients and treat them more effectively. The aim of this study was to examine the frequency of whole chromosome 9 loss (monosomy of chromosome 9) and its prognostic value in patients with ccRCC. Materials and Methods: Single nucleotide polymorphism-based chromosome microarray (CMA) analysis was performed on 103 resected specimens from patients with ccRCC who had undergone partial or radical nephrectomy between January 2002 and March 2017 at Fox Chase Cancer Center. Monosomy 9 was correlated with clinicopathologic parameters and recurrence-free survival. Results: Chromosome 9 loss was detected in 31 (30%) of 103 tumors. Tumors with chromosome 9 loss had higher histologic grade (3 and 4; P < .001) and pathologic stage (P < .001). In 59 patients with non-metastatic ccRCC, chromosome 9 loss was also associated with higher recurrence rate and shorter recurrencefree survival (RFS) (12-month RFS, 77.8%; 95% confidence interval, 36.5%-93.9% for chromosome 9 loss vs. 95.7%; 95% confidence interval, 84.0%-98.9% for no loss; P ¼ .002). Conclusions: Chromosome 9 loss was found in 30% of patients with ccRCC and correlated with higher grade, advanced stage, and shorter RFS in patients with Stage I to III ccRCC.

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Section: Introductionmentioning

confidence: 99%

Monosomy of Chromosome 9 Is Associated With Higher Grade, Advanced Stage, and Adverse Outcome in Clear-cell Renal Cell Carcinoma

Nejati

Wei

Uzzo

et al. 2020

Clinical Genitourinary Cancer

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“…NDRG1 expression can be upregulated by a variety of physiological conditions or external stimulus, which could promote cell differentiation. NDRG1 has been studied in breast (4,5), pancreatic (6)(7)(8), gastric cancer (9), colon (5,10), cervical (11), kidney cancer (12) and PCa (8,(13)(14)(15)(16), but the findings are not consistent. Whether NDRG1 has a role in tumor suppression or promotion remains controversial.…”

Section: Introductionmentioning

confidence: 99%

Downregulation of N-myc downstream regulated gene 1 caused by the methylation of CpG islands of NDRG1 promoter promotes proliferation and invasion of prostate cancer cells

Pan

Qiao

et al. 2015

International Journal of Oncology

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Current studies tend to consider N-myc downstream regulated gene 1 (NDRG1) as a tumor suppressor gene, inhibiting cell proliferation and invasion. NDRG1 expression in cancer cells is generally low, but the molecular mechanism is unclear. Aberrant methylation of CpG islands (CGIs) in gene promoter was able to inactivate tumor suppressor genes and activate oncogenes, disordering cell proliferation and apoptosis, playing a promotion role in tumor occurrence and progression. The present study was performed to investigate the effect of epigenetic modification of NDRG1 on prostate cancer (PCa) cells. The protein expression in human specimens was measured by immunohistochemical staining. The expression level of NDRG1 was changed by plasmid vectors in PCa cells. These cells were used to study proliferation and invasiveness. NDRG1 expression in normal prostate cells was higher than that in PCa cells. Downregulation of NDRG1 expression enhanced cell proliferation and invasiveness. In contrast, its upregulation could reduce cell proliferation and invasiveness. In PCa cells, the methylation rate of CGIs in the promoter region of NDRG1 was higher than that in normal prostate cells. 5-Aza-CdR, a methylation inhibitor, was able to effectively reverse the aberrant methylation of NDRG1, enhancing its expression, inhibiting cell growth. NDRG1 can inhibit the cell proliferation and invasion of PCa, but its expression level is low. The aberrant methylation of NDRG1 promoter is an important mechanism for gene silencing, playing an important role in tumor occurrence and progression. Therefore, reversing the aberrant methylation of NDRG1 may be used for PCa treatment.

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“…With a cancer‐type‐dependent function, NDRG1 was demonstrated to be highly expressed in cervical cancer and hepatocellular carcinoma , and its expression levels were found to be associated with tumor metastasis and poor prognosis. Paradoxically, most studies reported its functions in inhibition of cancer progression and metastasis . In CRC, NDRG1 expression was documented to be reduced in CRC tissues compared to the paired non‐tumor tissues and NDRG1 positive expression was a favorable prognostic factor for patients’ survival .…”

Section: Discussionmentioning

confidence: 99%

Knockdown of NDRG1 promote epithelial-mesenchymal transition of colorectal cancer via NF-κB signaling

Gao

Zeng

et al. 2016

J. Surg. Oncol.

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Proteomics identified nuclear N-myc downstream-regulated gene 1 as a prognostic tissue biomarker candidate in renal cell carcinoma

Cited by 30 publications

References 39 publications

Monosomy of Chromosome 9 Is Associated With Higher Grade, Advanced Stage, and Adverse Outcome in Clear-cell Renal Cell Carcinoma

Monosomy of Chromosome 9 Is Associated With Higher Grade, Advanced Stage, and Adverse Outcome in Clear-cell Renal Cell Carcinoma

Downregulation of N-myc downstream regulated gene 1 caused by the methylation of CpG islands of NDRG1 promoter promotes proliferation and invasion of prostate cancer cells

Knockdown of NDRG1 promote epithelial-mesenchymal transition of colorectal cancer via NF-κB signaling

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