Proteomics Blood Testing to Distinguish Chronic Rhinosinusitis Subtypes

Das, Subinoy; Maeso, Patricia; Becker, Adam M.; Prosser, J. Drew; Adam, Bao Ling; Kountakis, Stilianos E.

doi:10.1097/mlg.0b013e318182f7f4

Cited by 16 publications

(8 citation statements)

References 14 publications

(22 reference statements)

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“…Novel mathematical treatments of MALDI data have been conceived (Montazery-Kordy et al, 2008;Alexandrov et al, 2009;Liu, 2009). There remains an on-going documentation of blood by MALDI parent ion patterns in response to a variety of physiological states such as disease, drug response, the image or proximity of romantic partners or the use of performance enhancing drugs (Tammen et al, 2002;Guerrier, Lomas, & Boschetti, 2005;Schwegler et al, 2005;de Seny et al, 2005;Orvisky et al, 2006;Ragazzi et al, 2006;Zheng et al, 2006a;Lin et al, 2006b;de Noo et al, 2006b;Au et al, 2007;Cui et al, 2007Cui et al, , 2008bHui et al, 2007;Lim et al, 2007;Taguchi et al, 2007;Tiss et al, 2007;Yildiz et al, 2007;Das et al, 2008;Datta, 2008;Jacot et al, 2008;Kojima et al, 2008;Meuleman et al, 2008Meuleman et al, , 2009Ransohoff et al, 2008;Sundsten, Ostenson, & Bergsten, 2008a;Wei et al, 2008;Zinkin et al, 2008;Han et al, 2008a,b;Liu et al, 2008a;Wang et al, 2008aWang et al, ,c, 2008dCallesen et al, 2008bCallesen et al, , 2009Sundsten et al, 2008b;Albitar et al, 2009;Caron et al, 2009;…”

Section: Maldi Pattern Analysismentioning

confidence: 98%

Mass spectrometry of peptides and proteins from human blood

Zhu

Bowden

Zhang

et al. 2010

Mass Spectrometry Reviews

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It is difficult to convey the accelerating rate and growing importance of mass spectrometry applications to human blood proteins and peptides. Mass spectrometry can rapidly detect and identify the ionizable peptides from the proteins in a simple mixture and reveal many of their post-translational modifications. However, blood is a complex mixture that may contain many proteins first expressed in cells and tissues. The complete analysis of blood proteins is a daunting task that will rely on a wide range of disciplines from physics, chemistry, biochemistry, genetics, electromagnetic instrumentation, mathematics and computation. Therefore the comprehensive discovery and analysis of blood proteins will rank among the great technical challenges and require the cumulative sum of many of mankind's scientific achievements together. A variety of methods have been used to fractionate, analyze and identify proteins from blood, each yielding a small piece of the whole and throwing the great size of the task into sharp relief. The approaches attempted to date clearly indicate that enumerating the proteins and peptides of blood can be accomplished. There is no doubt that the mass spectrometry of blood will be crucial to the discovery and analysis of proteins, enzyme activities, and post-translational processes that underlay the mechanisms of disease. At present both discovery and quantification of proteins from blood are commonly reaching sensitivities of ∼1 ng/mL.

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Section: Maldi Pattern Analysismentioning

confidence: 98%

Mass spectrometry of peptides and proteins from human blood

Zhu

Bowden

Zhang

et al. 2010

Mass Spectrometry Reviews

View full text Add to dashboard Cite

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“…Although most of the complement factors are produced in the liver, the increased expression of factor B and C3 not only suggests the involvement of the alternative pathway of activation, but also that these factors (in the absence of increased expression of the terminal proteins) could be locally produced by the airway epithelial cells [50]. The other microarray [45–48] and proteomic [51–55] studies, by their nature, have not investigated the involvement of the innate immunity directly but show (in addition to innate immunity–related genes and proteins) the global effects of the ongoing inflammation and its potential use as a predictor of treatment outcome or clinical classification.…”

Section: A Global View On Innate Immunity and Chronic Rhinosinusitismentioning

confidence: 99%

Role of Innate Immunity in the Pathogenesis of Chronic Rhinosinusitis: Progress and New Avenues

Drunen

Mjösberg

Segboer

et al. 2012

Curr Allergy Asthma Rep

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Chronic rhinosinusitis is a heterogeneous and multifactorial disease with unknown etiology. Aberrant responses to microorganisms have been suggested to play a role in the pathophysiology of the disease. Research has focused on the presence, detection, response to, and eradication of these potential threats. Main topics seem to center on the contribution of structural cells such as epithelium and fibroblasts, on the consequences of activation of pattern-recognition receptors, and on the role of antimicrobial agents. This research should be viewed not only in the light of a comparison between healthy and diseased individuals, but also in a comparison between patients who do or do not respond to treatment. New players that could play a role in the pathophysiology seem to surface at regular intervals, adding to our understanding (and the complexity) of the disease and opening new avenues that may help fight this incapacitating disease.

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“…This work may then lead to the ability to carefully examine the interaction between coagulase-negative Staphylococcus aureus and antibiotics to enable a greater choice of medical treatment options. Beyond this, there has also been recent work by Das et al [56] to suggest that surface enhanced laser desorption/ionisation time-of-Xight mass spectrometry (SELDI-TOF-MS) proteomic proWling of serum samples may be used to distinguish chronic rhinosinusitis subtypes which in turn may allow for a blood test to highlight a severe subtype.…”

Section: Chronic Rhinosinusitismentioning

confidence: 96%

Nanomedicine in otorhinolaryngology: what does the future hold?

Philpott

Gane

McKiernan

2010

Eur Arch Otorhinolaryngol

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Nanotechnology and nanomedicine are new and rapidly developing areas which are concerned with the utilisation of structures and devices, one billionth of a metre in scale and how their special properties may be utilised in the diagnosis and treatment of diseases. In otorhinolaryngology, there have been some inroads into utilising these new treatment modalities and there is future prospect for significant developments. Their impact may be to revolutionise the current practice of otorhinolaryngology. This review considers current developments and future prospects for nanotechnology in our specialty and considers the pitfalls that may be encountered. The online medical reference databases PubMed, Google Scholar, ISI Web of Science and Science Direct were searched with search terms "Nanotechnology, Nanomedicine" in combination with "Otolaryngology, ENT, Rhinology, Otology, Head and Neck Surgery, Laryngology" in turn. A number of developments are already showing promise in animal models, particularly for nanoparticle delivery of drugs, which may avoid some of the inherent systemic side effects seen with conventional application. Other possibilities include nanoscale reconstruction and regeneration of tissues and even unexpected spin-off technologies such as haemostatic agents. The future treatment of otorhinolaryngological diseases could be revolutionised by advances in nanomedicine and nanotechnology and diseases, such as olfactory disorders may become radically more amenable to medical treatment.

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Proteomics Blood Testing to Distinguish Chronic Rhinosinusitis Subtypes

Cited by 16 publications

References 14 publications

Mass spectrometry of peptides and proteins from human blood

Mass spectrometry of peptides and proteins from human blood

Role of Innate Immunity in the Pathogenesis of Chronic Rhinosinusitis: Progress and New Avenues

Nanomedicine in otorhinolaryngology: what does the future hold?

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