Proteomics-Based Approach Identified Differentially Expressed Proteins With Potential Roles in Endometrial Carcinoma

Li, Zhengyu; Min, Wenjiao; Huang, Canhua; Bai, Shujun; Tang, Minghai; Zhao, Xia

doi:10.1111/igc.0b013e3181a9026d

Cited by 20 publications

(27 citation statements)

References 18 publications

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“…Survival analysis has indicated that CAPS is a potential survival predictor in breast cancer patients receiving adjuvant tamoxifen (25). Previous studies also revealed that CAPS was an independent prognostic factor for endometrial cancer patients (15,24) and colorectal cancer patients (17 (Fig. 3).…”

Section: Discussionmentioning

confidence: 89%

“…For example, CAPS was significantly down regulated in the bronchoalveolar lavage fluid of sulfur mustard-exposed patients when compared with healthy controls (12). Previous studies also showed that CAPS was overexpressed in ovarian cancer (13), ependymoma (14), endometrial cancer (15), lung cancer (16) and colorectal cancer (17). Another previous study revealed that CAPS promoted cancer progression and may be a prognostic indicator in colorectal cancer patients (17).…”

Section: Introductionmentioning

confidence: 96%

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Overexpression of calcyphosine is associated with poor prognosis in esophageal squamous cell carcinoma

Zhu

Yang

et al. 2017

Oncol Lett

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Abstract. Calcyphosine (CAPS), a calcium-binding protein, has been identified as a potential diagnostic and prognostic biomarker in several human carcinomas. However, little is known about CAPS in esophageal squamous cell carcinoma (ESCC). The present study aimed to investigate the expression levels of CAPS in ESCC tissues and evaluate its clinicopathological significance. Reverse transcription-quantitative polymerase chain reaction and immunohistochemical staining were conducted to detect the expression of CAPS in ESCC tissues and adjacent non-cancerous tissues. ESCC samples exhibited higher levels of CAPS mRNA than paired non-cancerous samples (P=0.0015), and the mRNA level of CAPS was positively associated with histological grade (P=0.0013) and tumor invasion depth (P=0.0206). In addition, Kaplan-Meier survival analysis revealed that patients with high CAPS expression experienced significantly shorter 5-year overall survival times than those with low CAPS expression (P=0.0112). Multivariate analysis demonstrated that CAPS protein expression was an independent prognostic biomarker for patients with ESCC. In conclusion, the findings of the present study demonstrated that CAPS may represent a novel diagnostic indicator and an independent prognostic biomarker in ESCC.

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Section: Discussionmentioning

confidence: 89%

Section: Introductionmentioning

confidence: 96%

Overexpression of calcyphosine is associated with poor prognosis in esophageal squamous cell carcinoma

Zhu

Yang

et al. 2017

Oncol Lett

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“…Additionally, increase in both E-FABP and CAPS in relation to EC were also reported in a different paper [12]. Implementing this method, both papers conclude that the overexpression of E-FABP and CAPS is correlated to histodifferentiation but not to clinical staging [11,12].…”

Section: Proteomicsmentioning

confidence: 83%

“…A study performed by Li et al exemplifies the value of proteomics where three potential EC-associated proteins were identified; Cyclophilin A (CypA), epidermal fatty acid-binding protein (E-FABP), and caclyphosine (CAPS) [11]. Additionally, increase in both E-FABP and CAPS in relation to EC were also reported in a different paper [12]. Implementing this method, both papers conclude that the overexpression of E-FABP and CAPS is correlated to histodifferentiation but not to clinical staging [11,12].…”

Section: Proteomicsmentioning

confidence: 94%

Biological markers with potential clinical value in endometrial cancer — review of the literature

et al. 2017

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Endometrial carcinoma (EC) is the most common malignancy of the female genital tract encountered in western countries, making it the fourth most common cancer in women. The incidence of uterine cancer is on the rise throughout the developed world where diagnosis is increasingly observed among younger patients. With regard to this, attention has been focused on conducting more studies to achieve a better understanding of the molecular genetics related to endometrial carcinogenesis. Over the years, EC has been classified into two broad histopathological subtypes based on the mechanism of development, and we can therefore observe specific biomarkers related to the respective subtype. Based on this idea, more research has been carried out in the last decade, using biotechnological methods, with the aim to identify new potential tumor markers. By translating these findings into clinical use one may facilitate accurate diagnosis and prognostic prediction, and contribute to individualized treatment. Without a doubt, there is a demanding need to identify biomarkers that can be adopted in clinical practice in order to reduce the time needed to obtain diagnosis. Such markers may be of great value in improving patient outcome. However, a number of problems remain to be solved before this becomes a reality. This paper briefly reviews the current status of rising biomarkers in EC.

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“…It is phosphorylated in a cAMP-dependent manner and thus may be implicated in the cross-signaling between these cascades to coordinate cell proliferation and differentiation (9), suggesting its involvment in carcinogenesis. It has been proven that CAPS is expressed in many tumors; overexpression of CAPS occurs in ependymoma (23), lung cancer (24), ovarian cancer (25) and endometrial cancer (26).…”

Section: Discussionmentioning

confidence: 99%

miR-219-5p suppresses the proliferation and invasion of colorectal cancer cells by targeting calcyphosin

et al. 2017

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Abstract. MicroRNAs (miRNAs) are small non-coding RNAs involved in an array of biological processes, and their dysregulation is associated with tumor development and progression. One such miRNA, miR-219-5p, is abnormally expressed in patients with colorectal cancer (CRC). In the present study, reverse transcription-quantitative polymerase chain reaction was performed to measure miR-219-5p expression in cells from both CRC tumors, and surrounding healthy tissue. MTT and invasion assays were used to determine the role of miR-219-5p in regulating CRC cell proliferation and invasion, respectively. A luciferase assay was then performed to assess the binding of miR-219-5p to the CAPS gene that encodes calcyphosin protein. The present study confirmed that miR-219-5p expression is significantly downregulated in CRC tissue. miR-219-5p knockdown promoted the growth of HCT-8 cells and increased the expression of calcyphosin protein (CAPS). On the other hand, overexpressing miR-219-5p inhibited HCT-8 cell growth and invasion, and downregulated CAPS expression. In addition, CAPS was identified as the functional downstream target of miR-219-5p by directly targeting its 3'-untranslated region. Therefore, miR-219-5p may function as a tumor suppressor by decreasing CAPS expression, and subsequently inhibit tumor proliferation and invasion. These results indicate that novel therapeutic strategies that increase miR-219-5p expression may be developed to treat CRC.

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Proteomics-Based Approach Identified Differentially Expressed Proteins With Potential Roles in Endometrial Carcinoma

Cited by 20 publications

References 18 publications

Overexpression of calcyphosine is associated with poor prognosis in esophageal squamous cell carcinoma

Overexpression of calcyphosine is associated with poor prognosis in esophageal squamous cell carcinoma

Biological markers with potential clinical value in endometrial cancer — review of the literature

miR-219-5p suppresses the proliferation and invasion of colorectal cancer cells by targeting calcyphosin

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