Proteomics and metabolomics analysis of nasal lavage fluid in chronic rhinosinusitis with nasal polyps

Yang, Yujuan; Guo, Jing; Yao, Yao; Wang, Jianwei; Yin, Jiali; Guo, Ying; Cai, Wei; Song, Xicheng

doi:10.1002/alr.23151

Cited by 2 publications

(4 citation statements)

References 15 publications

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“…Multi-omics studies combining proteomics and metabolomics are promising for enhancing the understanding of CRSwNP pathological processes. A study demonstrated the potential of combining these two omics to identify associations between amino acid metabolism, mitochondrial dysfunction, and CRSwNP pathogenesis ( 16 ). Furthermore, considering the regional and ethnic specificity of eCRSwNP, stratification and diagnosis at the molecular-level could significantly influence patient care and treatment.…”

Section: Discussionmentioning

confidence: 99%

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Recent advances in mass spectrometry-based proteomics and metabolomics in chronic rhinosinusitis with nasal polyps

Guo,

Tian,

Fan

et al. 2023

Front. Immunol.

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Chronic rhinosinusitis with nasal polyps (CRSwNP) is a complex and heterogeneous disease, typically diagnosed through endoscopy and computed tomography and treated with glucocorticoid or surgery. There is an urgent need to develop molecular-level diagnostic or prognostic tools to better understand the pathophysiology of CRSwNP. Proteomics and metabolomics, emerging fields, offer significant potential in elucidating the mechanisms underlying CRSwNP. Mass spectrometry, a powerful and sensitive tool for trace substance detection, is broadly applied for proteomics and metabolomics analysis in CRSwNP research. While previous literature has summarized the advancement of mass spectrometry-based CRSwNP proteomics from 2004 to 2018, recent years have seen new advances in this field, particularly about non-invasive samples and exosomes. Furthermore, mass spectrometry-based CRSwNP metabolomics research has opened new avenues for inquiry. Therefore, we present a comprehensive review of mass spectrometry-based proteomics and metabolomics studies on CRSwNP conducted between 2019 and 2022. Specifically, we highlight protein and metabolic biomarkers that have been utilized as diagnostic or prognostic markers for CRSwNP. Lastly, we conclude with potential directions for future mass spectrometry-based omics studies of CRSwNP.

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Section: Discussionmentioning

confidence: 99%

“…Recently, a novel proteomic method incorporated parallel reaction monitoring (PRM) scanning after traditional DIA to verify key proteins. This method has been successfully applied in CRSwNP ( 16 ).…”

Section: Introductionmentioning

confidence: 99%

Recent advances in mass spectrometry-based proteomics and metabolomics in chronic rhinosinusitis with nasal polyps

Guo,

Tian,

Fan

et al. 2023

Front. Immunol.

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“…Based on comprehensive proteomic and metabolomic analysis of nasal lavage fluid from CRSwNP patients, researchers found the possible therapeutic targets for CRSwNP. Their study revealed noteworthy alterations in key proteins and metabolites linked to mitochondrial function, as well as arginine and α‐linolenic acid metabolism, the “mitochondrial dysfunction,” “arginine biosynthesis,” and “α‐linolenic acid metabolism” were identified as crucial components associated with CRSwNP pathogenesis 38 . The other investigation on the proteomes of nasal mucus and mucosa indicated that alterations in sinonasal proteome caused the increased metabolic process in CRS 39 .…”

Section: Exploration Of Metabolomics In Crs Subtypesmentioning

confidence: 99%

“…Their study revealed noteworthy alterations in key proteins and metabolites linked to mitochondrial function, as well as arginine and α-linolenic acid metabolism, the "mitochondrial dysfunction," "arginine biosynthesis," and "α-linolenic acid metabolism" were identified as crucial components associated with CRSwNP pathogenesis. 38 The other investigation on the proteomes of nasal mucus and mucosa indicated that alterations in sinonasal proteome caused the increased metabolic process in CRS. 39 Notably, mitochondria serve as the primary sites for the production of reactive oxygen species (ROS).…”

Section: Metabolomics Explored In Crssnp and Crswnpmentioning

confidence: 99%

Decoding chronic rhinosinusitis: A metabolomics‐based approach

Gong,

Fu,

Zhou

et al. 2024

Int Forum Allergy Rhinol

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BackgroundChronic rhinosinusitis (CRS) is a common and intractable disease in otorhinolaryngology, laying a heavy burden on healthcare systems. The worldwide researchers are making efforts to find solutions to this disease. Metabolomics has recently gained more and more traction, and might become a promising tool to unravel the complexity of CRS. This paper provides an overview of current studies on the metabolomics of various CRS subtypes.MethodsWe conducted a comprehensive literature search in PubMed, Web of Science, EMBASE, Google Scholar, and Cochrane Library, up to May 25, 2023. Search strategies incorporated key terms such as “chronic rhinosinusitis” and “metabolomics” with relevant synonyms and MeSH terms. Titles and abstracts of 86 screened articles were assessed for relevance to CRS and metabolomics. Methodological robustness, data reliability, and relevance were considered for shortlisted articles.ResultsAfter the refined process, a total of 26 articles were included in this study and sorted out by research themes, methodology and pivotal discoveries. These included studies identified the metabolic pathways and markers related to the pathophysiology in each subtype of CRS.ConclusionsMetabolomics helps to shed light on the complexity of CRS. The mentioned findings highlight the importance of specific metabolic pathways and markers in understanding the pathophysiology of CRS. Despite that, challenges and future directions in metabolomics research for CRS would be worth being further explored.

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Proteomics and metabolomics analysis of nasal lavage fluid in chronic rhinosinusitis with nasal polyps

Abstract: Key Points An integrated proteomics and metabolomics were used to investigate the pathogenesis of CRSwNP. Amino acid metabolism and mitochondrial dysfunction play key roles in the pathogenesis of CRSwNP.

Cited by 2 publications

References 15 publications

Recent advances in mass spectrometry-based proteomics and metabolomics in chronic rhinosinusitis with nasal polyps

Recent advances in mass spectrometry-based proteomics and metabolomics in chronic rhinosinusitis with nasal polyps

Decoding chronic rhinosinusitis: A metabolomics‐based approach

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