Proteomics analysis of chicken peripheral blood lymphocyte in Taishan Pinus massoniana pollen polysaccharide regulation

Yang, Shifa; Zhao, Zengcheng; Zhang, Anyuan; Jia, Fengjuan; Song, Ming; Huang, Zhongli; Fu, Jing; Li, Guiming; Su, Lin

doi:10.1371/journal.pone.0208314

Cited by 4 publications

(4 citation statements)

References 35 publications

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“…CD4+ and CD8+ potentially play as cell-mediated immunity during the antibody synthesis and support to destruct the infected cells (Kempashi et al, 2017). The shrinkage of T cells subset in the lymphoid tissue dramatically changes the circulatory phenomenon not only in the haematological aspects but also the antibody synthesis (Yang et al, 2018).…”

Section: Dmentioning

confidence: 99%

Recent Update: Effects of Aflatoxin in Broiler Chickens

Kurniasih¹,

Prakoso²

2019

jwpr

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Aflatoxin is a worldwide problem in poultry industries as it is known to contaminate poultry feed. Aflatoxin induces stress and increases mortality rate during infection in poultry, especially broiler chickens. The objectives of this study was to observe the pathological effects due to aflatoxicosis in broiler chickens. A total of 120 chickens were divided into four groups, group A fed with a basal diet without aflatoxin contamination, group B with aflatoxin (> 1 ppb < 50 ppb), group C with aflatoxin (> 51 ppb < 100 ppb), group D with aflatoxin (> 101 ppb < 150 ppb). The data were collected and analysed on day 7, 14, and 21. The results showed that diet with high aflatoxin contamination in group D impaired the physical and laboratory performances of the chickens, increased the risk of residue in the poultry's final products. The varying doses of aflatoxin contamination in the chicken feed causes the problems on the broiler chickens with different level of severity.

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Section: Dmentioning

confidence: 99%

Recent Update: Effects of Aflatoxin in Broiler Chickens

Kurniasih¹,

Prakoso²

2019

jwpr

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“…Yang et al analyzed the effect of Taishan Pinus massoniana pollen polysaccharide on chicken peripheral blood lymphocyte proteome and identified 10 differentially expressed candidate proteins. Candidate proteins, and some differentially expressed proteins were associated with host innate immune response, stress-induced immune response and lipid synthesisrelated pathways (20). The intestine is the largest immune organ and contains a large number of immune cells (21).…”

Section: Introductionmentioning

confidence: 99%

The Effect of Flammulina velutipes Polysaccharide on Immunization Analyzed by Intestinal Flora and Proteomics

et al. 2022

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Proteomics and intestinal flora were used to determine the mechanism of immune modulatory effects of Flammulina velutipes polysaccharide on immunosuppressed mice. The results showed that compared with the model group, F. velutipes polysaccharide could increase thymus and spleen indices and improve thymus tissue structure in mice; IL-2 and IL-4 contents were significantly increased and IL-6 and TNF-α contents were significantly decreased; serum acid phosphatase (ACP), lactate dehydrogenase (LDH) and total antioxidant capacity (T-AOC) activities were increased (P < 0.05); in the liver, superoxide dismutase (SOD) and catalase (CAT) activities were increased (P < 0.001), while malondialdehyde (MDA) content was decreased (P < 0.001). Proteomics discovered that F. velutipes polysaccharides may exert immune modulatory effects by participating in signaling pathways such as immune diseases, transport and catabolism, phagosomes and influenza A, regulating the immune-related proteins Transferrin receptor protein 1 (TFRC) and Radical S-adenosyl methionine domain-containing protein 2 (RSAD2), etc. Gut microbial studies showed that F. velutipes polysaccharides could increase the abundance of intestinal flora and improve the flora structure. Compared to the model group, the content of short-chain fatty acids (SCFAs) and the relative abundance of SCFA-producers Bacteroides and Alloprevotella were increased in the F. velutipes polysaccharide administration group, while Lachnospiraceae_NK4A136_group and f_Lachnospiraceae_Unclassified decreased in relative abundance. Thus, F. velutipes polysaccharide may play an immunomodulatory role by regulating the intestinal environment and improving the balance of flora.

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“…A study reported that TPPPS can promote the proliferation and activation of poultry macrophages and enhance poultry resistance to pathogens by stimulating and activating lymphocytes and immunomodulatory functions by releasing cytokines IL-2 and TNF-α and increasing the chemical signaling mediator NO ( 65 ). Simultaneously, a proteomic study on peripheral blood lymphocytes of chickens treated with TPPPS showed that the differentially expressed proteins in the TPPPS group were related to host innate immune response and stress-induced immune response ( 66 ). The study also showed that in the model of poultry immunosuppression, TPPPS significantly enhanced the immune organ index of chickens, which enhanced the immune ability, promoted the differentiation and proliferation of CD4 + and CD8 + T lymphocytes, and significantly increased the levels of cytokines IL-2 and IFN-γ to mediate the immune response and enhance the immune system function of chickens ( 67 , 68 ).…”

Section: Plant Polysaccharidementioning

confidence: 99%

Research progress on the mechanisms underlying poultry immune regulation by plant polysaccharides

Zhao

Yang

Bai³

et al. 2023

Front. Vet. Sci.

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With the rapid development of poultry industry and the highly intensive production management, there are an increasing number of stress factors in poultry production. Excessive stress will affect their growth and development, immune function, and induce immunosuppression, susceptibility to a variety of diseases, and even death. In recent years, increasing interest has focused on natural components extracted from plants, among which plant polysaccharides have been highlighted because of their various biological activities. Plant polysaccharides are natural immunomodulators that can promote the growth of immune organs, activate immune cells and the complement system, and release cytokines. As a green feed additive, plant polysaccharides can not only relieve stress and enhance the immunity and disease resistance of poultry, but also regulate the balance of intestinal microorganisms and effectively alleviate all kinds of stress faced by poultry. This paper reviews the immunomodulatory effects and molecular mechanisms of different plant polysaccharides (Atractylodes macrocephala Koidz polysaccharide, Astragalus polysaccharides, Taishan Pinus massoniana pollen polysaccharide, and alfalfa polysaccharide) in poultry. Current research results reveal that plant polysaccharides have potential uses as therapeutic agents for poultry immune abnormalities and related diseases.

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Proteomics analysis of chicken peripheral blood lymphocyte in Taishan Pinus massoniana pollen polysaccharide regulation

Cited by 4 publications

References 35 publications

Recent Update: Effects of Aflatoxin in Broiler Chickens

Recent Update: Effects of Aflatoxin in Broiler Chickens

The Effect of Flammulina velutipes Polysaccharide on Immunization Analyzed by Intestinal Flora and Proteomics

Research progress on the mechanisms underlying poultry immune regulation by plant polysaccharides

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