Proteomic Study on the Protective Effect of Tanshinone IIA Against Oxidative Injury to Human Umbilical Vein Endothelial Cells by Hydrogen Peroxide

Teng, Yao-hong; Lu, De-zhao; Fan, Chunlei; Dong, Yuchen; Zhu, Jing

doi:10.2174/1570164610999131125102832

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“…A gradual accumulation of evidence has revealed that it offers some remedial relief for angina pectoris, hyperlipidemia, and acute ischemic stroke. Salvia has also been used in Japan, the United States, and European countries for the treatment of cardiovascular and cerebrovascular diseases. , Salvia promotes endothelial cell adhesion, and it also protects endothelial cells via antioxidative apoptosis and can promote the migration of endothelial cells. − Additionally, salvia can affect the adhesion of platelets and can retard platelet activity by inhibiting platelet aggregation and thrombus formation. , It also affects some disease of the nerves and bones. − Salvianolic acid B (SAB) is obtained by extraction and purification from salvia, and it has antioxidative, anti-inflammatory, antihypoxic, antiarteriosclerotic, and antiapoptotic properties. This substance can also ameliorate brain injury or neurodegenerative diseases .…”

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confidence: 99%

A Method for Preparation of an Internal Layer of Artificial Vascular Graft Co-Modified with Salvianolic Acid B and Heparin

Kuang

Wang

et al. 2018

ACS Appl. Mater. Interfaces

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Studies have shown that salvianolic acid B (SAB), which is derived from Chinese salvia ( Salvia miltiorrhiza), a plant used in traditional Chinese medicine, can promote the proliferation and migration of endothelial cells. The inner layer of an artificial vascular graft was fabricated using the coaxial electrospinning method and was loaded with the anticoagulant heparin and SAB. The release of heparin and SAB was sustained for almost 30 days and without an initial burst release of SAB. Furthermore, the combined effect of SAB and heparin contributed to promoting human umbilical vein endothelial cell (HUVEC) growth and improved the blood compatibility of the graft. In addition, upregulation of GRP78 by SAB protected human endothelial cells from oxidative stress-induced cellular damage. In vivo evaluation through Masson's trichrome and H&E staining was performed after the graft was subcutaneously embedded in SD rats for 2 weeks and indicated that the graft possessed satisfactory biocompatibility and did not cause a significant immune response. Hence, the functional inner layer is promising for preventing acute thrombosis and promotes rapid endothelialization of artificial vascular grafts.

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