Proteomic profiling reveals crucial retinal protein alterations in the early phase of an experimental glaucoma model

Abstract

In conclusion, these results provide further lines of evidence that substantial molecular changes occur at the onset of the disease, identifying potential key players, which might be useful as biomarkers for diagnostics and development of medical treatment in the future.

Hydrogen Sulfide Protects Retinal Ganglion Cells Against Glaucomatous Injury In Vitro and In Vivo

“…IOP was elevated through thermic cauterization of episcleral veins, inducing experimental glaucoma previously shown by Anders et al 16 In parallel with the IOP elevation, the number of RGCs (839.3 6 215.4 RGC/mm 2 ) decreased by approximately 20% (***P < 0.001), compared with the contralateral controls (1070.4 6 191.2 RGC/mm 2 ) (Fig. 3).…”

17β-Estradiol Delivered in Eye Drops: Evidence of Impact on Protein Networks and Associated Biological Processes in the Rat Retina through Quantitative Proteomics

“…It is expected that the wealth of information from this report will be valuable for neuroprotective ophthalmic therapy development relying on repurposing [6,8], polypharmacology [9], and target-focused new drug discovery [28], as well as for actual preventative medication aimed specifically at preserving the function of retinal ganglion cells (RGCs) from the postmenopausal impact of estrogen deficiency [29] alike. This expectation is justified especially in the context of emerging results from similar omics-driven profiling experiments on neurodegenerative diseases of the human eye [30] or animal models thereof [31][32][33][34].…”

Erhöhter Augeninnendruck für 7 Wochen induziert lokale Gefäßveränderungen im experimentellen Glaukommodell in vivo

“…Auch werden die in der RNFL befindlichen Gefäße mitberücksichtigt und können das Ergebnis verfälschen. Anders et al haben in ihren Studien allerdings die durch RNFL-Verkleinerung in OCT-Aufnahmen von Ratten angedeutete Neurodegeneration mit Auszählen der retinalen Ganglienzellen (RGC) nachgewiesen [22].…”