Proteomic profiling reveals ACSS2 facilitating metabolic support in acute myeloid leukemia
Liliana H. Mochmann,
Denise Treue,
Michael Bockmayr
et al.
Abstract:Acute myeloid leukemia (AML) is a heterogeneous disease characterized by genomic aberrations in oncogenes, cytogenetic abnormalities, and an aberrant epigenetic landscape. Nearly 50% of AML cases will relapse with current treatment. A major source of therapy resistance is the interaction of mesenchymal stroma with leukemic cells resulting in therapeutic protection. We aimed to determine pro-survival/anti-apoptotic protein networks involved in the stroma protection of leukemic cells. Proteomic profiling of cult… Show more
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