Proteomic profiling of splenic interstitial fluid of malnourished mice infected with Leishmania infantum reveals defects on cell proliferation and pro-inflammatory response

Losada-Barragán, Mónica; Umaña‐Pérez, Adriana; Rodríguez-Vega, Andrés; Cuervo-Escobar, Sergio; Azevedo, Renata; Morgado, Fernanda Nazaré; Carvalho, Vinícius F.; Aquino, Priscila Ferreira de; Carvalho, Paulo C.; Porrozzi, Renato; Sánchez-Gómez, Myriam; Padrón, Gabrìel; Cuervo, Patrícia

doi:10.1016/j.jprot.2019.103492

Cited by 8 publications

(15 citation statements)

References 65 publications

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“…infantum Flow Cytometry; ITRAQ; Nano LC–MS/MS Protein Malnourished infected vs well nutritioned un-infected 38 71 2019 [ 43 ] 8 L . infantum ITRAQ; Nano LC–MS/MS Malnourished infected vs well nutritioned un-infected and Well nutritioned infected vs well nutritioned un-infected 35 60 2019 [ 44 ] 9 L . amazonensis and L .…”

Section: Differentially Modulated Proteins In the Host After mentioning

confidence: 99%

“…Overall, the studies by Negrão et al [ 40 , 42 , 41 ] demonstrated the species-specific protein modulation in Leishmania infection as well as differentiated the host response through LPS inoculation and Leishmania infection. To observe the immune response effects of malnutrition in Leishmania infection, Losada-Barragán et al [ 43 , 44 ] conducted the differential proteomic studies involving malnourished mice. In both their studies [ 43 , 44 ], they compared the proteomes of protein-malnourished mice (infected with L. infantum ) and uninfected well-nourished mice.…”

Section: Differentially Modulated Proteins In the Host After mentioning

confidence: 99%

“…To observe the immune response effects of malnutrition in Leishmania infection, Losada-Barragán et al [ 43 , 44 ] conducted the differential proteomic studies involving malnourished mice. In both their studies [ 43 , 44 ], they compared the proteomes of protein-malnourished mice (infected with L. infantum ) and uninfected well-nourished mice. In the study involving thymic tissue samples [ 43 ], 38 and 71 proteins are up-regulated and down-regulated in infected malnourished subjects, respectively.…”

Section: Differentially Modulated Proteins In the Host After mentioning

confidence: 99%

“…In the study involving thymic tissue samples [ 43 ], 38 and 71 proteins are up-regulated and down-regulated in infected malnourished subjects, respectively. In the study involving splenic interstitial fluid [ 44 ], 35 and 60 proteins are up-regulated and down-regulated in infected malnourished subjects, respectively. These studies concluded that the protein malnutrition reduces the pro-inflammatory response towards a Leishmania infection.…”

Section: Differentially Modulated Proteins In the Host After mentioning

confidence: 99%

“…Hence, amastigotes are the cause of disease in the mammalian host [ 4 ]. Leishmaniasis is mainly associated with the weak immune system, malnutrition, and poor housing [ 5 ], thus majorly affecting the poor population of Africa, Asia, and Latin America. Since more than 90 countries are endemic for leishmaniasis [ 6 ], it is considered one of the major neglected tropical diseases of serious concern worldwide.…”

Section: Introductionmentioning

confidence: 99%

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Differentially modulated proteins associated with Leishmaniasis—a systematic review of in-vivo and in-vitro studies

2020

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High-throughput proteomic technologies are widely used for understanding the disease mechanism, drug-resistant mechanism, and to identify drug targets and markers for diagnostics. Studies with proteomics applications, relating to Leishmaniasis, are being constantly reported in the literature. However, from such studies, a readily accessible knowledge of differentially modulated proteins associated with Leishmaniasis is lacking. Hence, we performed a systematic review concerning differentially modulated proteins (DMP) in Leishmania as well as host infected with Leishmania from the published articles between the years 2000 and 2019. This review is classified into five different sections, namely, DMP in the host after Leishmania infection, DMP between different strains of Leishmania , DMP in drug-resistant Leishmania , DMP in Leishmania under stress, and DMP in different life stages of Leishmania. A lot of consensuses could be observed among the DMP in drug-resistant and stressed Leishmania . In addition to the review, a database was constructed with the data collected in this study (protein accession ID, protein name, gene name, host organism, experimental conditions, fold change, and regulatory data). A total of 2635 records are available in the database. We believe this review and the database will help the researcher in understanding the disease better and provide information for the targeted proteomics study related to Leishmaniasis. Database availability: http://ldepdb.biomedinformri.com/ . Electronic supplementary material The online version of this article (10.1007/s11033-020-05936-z) contains supplementary material, which is available to authorized users.

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