Proteomic profiling of lung diffusion impairment in the recovery stage of SARS‐CoV‐2–induced ARDS

García-Hidalgo, María C.; González, Jessica; Carmona, Paola; Santisteve, Sally; Moncusí‐Moix, Anna; Gort‐Paniello, Clara; Rodríguez-Jara, Fátima; Molinero, Marta; Perez-Pons, Manel; Torres, Gerard; Caballero, Jesús; Barberà, Carme; Tedim, Ana P.; Almansa, Raquel; Ceccato, Adrián; Fernández-Barat, Laia; Ferrer, Ricard; Garcia-Gasulla, Darío; Menéndez, Rosário; Motos, Ana; Peñuelas, Óscar; Riera, Jordi; Bermejo-Martín, Jesús F.; Torres, Antoni; Barbé, Ferrán; Gonzalo-Calvo, David de

doi:10.1002/ctm2.838

Cited by 6 publications

(6 citation statements)

References 15 publications

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“…In fact, the downregulation of PPP1R10 and SNRPG has been previously linked to reduced cellular proliferation and cell cycle arrest, respectively [51] , [52] . These results are in accordance with previous data that link proteomic mediators of cell proliferation and differentiation with pulmonary sequelae in severe COVID-19 [16] . Several genes in the classification model, such as TMEM161B , ENPP5 , and BAG2 , mediate a wide range of cellular processes, including protein synthesis.…”

Section: Discussionsupporting

confidence: 93%

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Genome-wide transcriptional profiling of pulmonary functional sequelae in ARDS- secondary to SARS-CoV-2 infection

García-Hidalgo

Peláez

González

et al. 2022

Biomedicine & Pharmacotherapy

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Section: Discussionsupporting

confidence: 93%

“…Gaining a better understanding of the molecular underpinnings that mediate persistent lung dysfunction could aid the development of therapeutics and biomarkers for post-COVID sequelae [16] . In this context, whole-blood transcriptomic analysis will reveal unexpected or unknown mediators in the pathogenesis of post-acute lung sequelae.…”

Section: Introductionmentioning

confidence: 99%

Genome-wide transcriptional profiling of pulmonary functional sequelae in ARDS- secondary to SARS-CoV-2 infection

García-Hidalgo

Peláez

González

et al. 2022

Biomedicine & Pharmacotherapy

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“…Given the significant burden of pulmonary sequelae caused by SARS-CoV-2 and the current lack of evidence to treat lung dysfunction in “post-COVID” syndrome, the development of innovative therapies is of vital importance. In this scenario, molecular phenotyping of the patient emerges as an essential tool to identify the underlying biological factors implicated in the sequelae and, consequently, targets for intervention [ 12 ].…”

Section: Introductionmentioning

confidence: 99%

Identification of circulating microRNA profiles associated with pulmonary function and radiologic features in survivors of SARS-CoV-2-induced ARDS

García-Hidalgo

González

Carmona

et al. 2022

Emerging Microbes & Infections

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There is a limited understanding of the pathophysiology of postacute pulmonary sequelae in severe COVID-19. The aim of current study was to define the circulating microRNA (miRNA) profiles associated with pulmonary function and radiologic features in survivors of SARS-CoV-2-induced ARDS. The study included patients who developed ARDS secondary to SARS-CoV-2 infection (n = 167) and a group of infected patients who did not develop ARDS (n = 33). Patients were evaluated 3 months after hospital discharge. The follow-up included a complete pulmonary evaluation and chest computed tomography. Plasma miRNA profiling was performed using RT-qPCR. Random forest was used to construct miRNA signatures associated with lung diffusing capacity for carbon monoxide (D LCO ) and total severity score (TSS). Kyoto Encyclopedia of Genes and Genomes (KEGG) and Gene Ontology (GO) enrichment analyses were conducted. D LCO < 80% predicted was observed in 81.8% of the patients. TSS showed a median [P 25 ;P 75 ] of 5 [2;8]. The miRNA model associated with D LCO comprised miR-17-5p, miR-27a-3p, miR-126-3p, miR-146a-5p and miR-495-3p. Concerning radiologic features, a miRNA signature composed by miR-9-5p, miR-21-5p, miR-24-3p and miR-221-3p correlated with TSS values. These associations were not observed in the non-ARDS group. KEGG pathway and GO enrichment analyses provided evidence of molecular mechanisms related not only to profibrotic or anti-inflammatory states but also to cell death, immune response, hypoxia, vascularization, coagulation and viral infection. In conclusion, diffusing capacity and radiological features in survivors from SARS-CoV-2-induced ARDS are associated with specific miRNA profiles. These findings provide novel insights into the possible molecular pathways underlying the pathogenesis of pulmonary sequelae. Trial registration: . Trial registration: .

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“…García‐Hidalgo et al. reported that the diffusion capacity and radiological features of survivors of SARS‐CoV‐2‐induced acute respiratory distress syndrome were associated with specific miRNA profiles [24, 25].…”

Section: Discussionmentioning

confidence: 99%

Residual pulmonary infiltrates, symptoms and diffusion impairment at 1‐year after severe COVID‐19 infection have different associated factors

et al. 2023

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Introduction.After severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) pneumonia, patients may show lung sequelae on radiology and functional impairment at the 1-year followup. We aimed to describe the persistence of symptoms, radiological alterations, or reduced diffusing capacity of the lung for carbon monoxide (D LCO ) at 1-year follow-up in patients from the Spanish Registry RECOVID.Methods. RECOVID collected symptom and radiological and functional lung tests data on hospitalized patients with coronavirus disease 2019 during the acute phase and at the 6-and 12-month followup visits.Results. Of the 2500 enrolled survivors (90% admitted to the ward), 1874 had follow-up visits for up to a year. Of these, 42% continued to present with symptoms, 27% had radiological sequelae and 31% had reduced D LCO . Independently associated factors included female sex, asthma and the requirement for invasive or non-invasive mechanical ventilation. Complete radiological resolution was 72.2% at 12 months; associated factors with incomplete recovery were age, male sex, oxygen or respiratory support, corticosteroids and an initial SpO 2 /FiO 2 <450 or CURB-65 ≥2. Reduced D LCO was observed in 31% of patients at 12 months; associated factors were older age, female sex, smoking habit, SpO 2 /FiO 2 <450 and CURB-65 ≥2 and the requirement of respiratory support.At 12 months, a proportion of the asymptomatic patients showed reduced D LCO (9.5%), radiological findings (25%) or both (11%).Conclusions. The factors associated with symptom persistence, incomplete radiological resolution and

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Proteomic profiling of lung diffusion impairment in the recovery stage of SARS‐CoV‐2–induced ARDS

Cited by 6 publications

References 15 publications

Genome-wide transcriptional profiling of pulmonary functional sequelae in ARDS- secondary to SARS-CoV-2 infection

Genome-wide transcriptional profiling of pulmonary functional sequelae in ARDS- secondary to SARS-CoV-2 infection

Identification of circulating microRNA profiles associated with pulmonary function and radiologic features in survivors of SARS-CoV-2-induced ARDS

Residual pulmonary infiltrates, symptoms and diffusion impairment at 1‐year after severe COVID‐19 infection have different associated factors

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