Proteomic profiling identifies SPP1 associated with rapidly progressive interstitial lung disease in anti-MDA5-positive dermatomyositis
Yulu Qiu,
Xiaoke Feng,
Chang Liu
et al.
Abstract:Background
Anti-melanoma differentiation-associated gene five antibody positive (MDA5+) dermatomyositis (DM) is significantly associated with rapidly progressive interstitial lung disease (RP-ILD). Early detection of RP-ILD remains a major challenge. This study aims to identify and validate prognostic factors for RP-ILD in MDA5+ DM patients.
Methods
Plasma samples from 20 MDA5+ DM patients and 10 healthy controls (HC) were collected for proteomic a… Show more
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