Proteomic profile of the effects of low-dose bisphenol A on zebrafish ovaries

Molina, A.; Abril, Nieves; Lora, Antonio; Huertas-Abril, Paula V.; Ayala, Nahúm; Blanco, Carmen; Moyano, M.R.

doi:10.1016/j.fct.2021.112435

Cited by 15 publications

(6 citation statements)

References 88 publications

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“…Zebrafish is an excellent species for proteomic, genomic, and transcriptomic analyses because it is a well-characterized vertebrate animal model widely used in genetics, physiology, and immunology (Lü et al 2014;Sullivan & Kim 2008). The zebrafish genome has been completely sequenced and largely annotated, which makes it simpler to discover and describe proteins using proteomic analysis in conjunction with existing databases (Molina et al 2021;Toni et al 2019). Furthermore, proteomics data collected on zebrafish can serve as a valuable resource for future research into protein networks and biological evolution.…”

Section: Discussionmentioning

confidence: 99%

Proteomic analysis of zebrafish (Danio rerio) embryos exposed to benzyl benzoate

Kwon

Park

Lee

et al. 2022

Environ Sci Pollut Res

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Benzyl benzoate (BB) is widely used in the food, cosmetics, agriculture, and pharmaceutical industries and is discharged into the aquatic environment via various water sources, including wastewater. Research on the bioaccumulation and possible toxicity of BB has been conducted, but the biochemical responses to BB toxicity are not fully understood, and the specific molecular pathways by which BB causes toxicity remain unknown. In this study, label-free quantitative proteomics based on mass spectrometry was applied to investigate protein profiles in zebrafish (Danio rerio) embryos exposed to BB (1 µg/mL) for 7 days. A total of 83 differentially expressed proteins (DEPs) were identified, including 49 up-regulated and 34 down-regulated proteins. The biological functions of proteins regulated by BB were grouped into functional categories and subcategories, including the biosynthesis of organonitrogen compound biosynthetic process, translation, amide biosynthetic process, lipid transport, stress response, and cytoskeletal activity. The results provide novel insight into the molecular basis of the ecotoxicity of BB in aquatic ecosystems.

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Section: Discussionmentioning

confidence: 99%

Proteomic analysis of zebrafish (Danio rerio) embryos exposed to benzyl benzoate

Kwon

Park

Lee

et al. 2022

Environ Sci Pollut Res

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“…Moreover, the compilation of proteomic data using the zebrafish animal model can serve as a valuable resource for future studies focused on protein networks and biological evolution. Zebrafish complete genome sequencing enables the discovery and characterization of proteins through proteomics, leveraging integration with existing databases [134]. Proteomic analysis unveiled that benzyl benzoate had a significant impact on proteins involved in the biosynthesis of organonitrogen compounds, translation, lipid transport, stress responses, and cytoskeletal activity [135].…”

Section: Omics Technologiesmentioning

confidence: 99%

The Zebrafish as an Alternative Animal Model for Ecotoxicological Research and Testing

Braga,

Souza,

Lima

et al. 2024

Braz. arch. biol. technol.

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Anthropogenic interventions have had a compromising effect on environmental health, intensifying the degradation of ecosystems, and the quantity of chemical pollutants released into nature. Therefore, research areas within the scope of environmental assessments and monitoring such as ecotoxicology have contributed to the determination of the toxic potential of contaminants. A small cyprinid known as the zebrafish (Danio rerio), the use of which has exponentially grown, is an alternative vertebrate model for scientific research, mainly in the assessment of environmental risks. The species exhibits several advantages for breeding in a laboratory, in addition to presenting multi-biomarkers of environmental toxicity. Thus, this review aims to present the main characteristics and advantages of working with this species, as well as show studies related to ecotoxicology involving biomarkers of toxicity in zebrafish. The results show a progressive trend towards employing the species in environmental risk analyses, it is an increasingly recommended species in the assessment of the toxicity level of a range of chemical pollutants. The development of future technologies must contribute to scientific advancement, rendering the potential application of this model organism an even more widespread one, which will certainly help in bridging knowledge gaps in various areas of study.

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“…BPA is closely linked to immune function, inflammation, and oxidative stress [15,135]. It can also induce mitochondrial damage and cell apoptosis [136].…”

Section: Immunological Effects On Oxidative Stress and Inflammationmentioning

confidence: 99%

An Overview of the Health Effects of Bisphenol A from a One Health Perspective

Molina-López

Bujalance-Reyes

Ayala-Soldado

et al. 2023

Animals

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Bisphenol A (BPA) is a chemical compound, considered as an “emerging pollutant”, that appears ubiquitously, contaminating the environment and food. It is an endocrine disruptor, found in a multitude of consumer products, as it is a constituent of polycarbonate used in the manufacture of plastics and epoxy resins. Many studies have evaluated the effects of BPA, using a wide range of doses and animal models. In this work, we carried out a review of relevant research related to the effects of BPA on health, through studies performed at different doses, in different animal models, and in human monitoring studies. Numerous effects of BPA on health have been described; in different animal species, it has been reported that it interferes with fertility in both females and males and causes alterations in their offspring, as well as being associated with an increase in hormone-dependent pathologies. Similarly, exposure to BPA has been related to other diseases of great relevance in public health such as obesity, hypertension, diabetes, or neurodevelopmental disorders. Its ubiquity and nonmonotonic behavior, triggering effects at exposure levels considered “safe”, make it especially relevant when both animal and human populations are constantly and inadvertently exposed to this compound. Its effects at low exposure levels make it essential to establish safe exposure levels, and research into the effects of BPA must continue and be focused from a “One Health” perspective to take into account all the factors that could intervene in the development of a disease in any exposed organism.

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Proteomic profile of the effects of low-dose bisphenol A on zebrafish ovaries

Cited by 15 publications

References 88 publications

Proteomic analysis of zebrafish (Danio rerio) embryos exposed to benzyl benzoate

Proteomic analysis of zebrafish (Danio rerio) embryos exposed to benzyl benzoate

The Zebrafish as an Alternative Animal Model for Ecotoxicological Research and Testing

An Overview of the Health Effects of Bisphenol A from a One Health Perspective

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