Proteomic profile of serum from patients with schizophrenia spectrum disorders

Abstract

This article describes the most likely classes of proteins and molecular processes that specifically characterize schizophrenic spectrum disorders such as simple and paranoid schizophrenia, schizotypal disorder, and acute polymorphic psychotic disorder (APPD). The identification of patients’ serum proteins was carried out using mass spectrometry. For patients with paranoid schizophrenia, the proteins responsible for translation and transcription are characteristic. A significant part of the proteins of patients with simple schizophrenia regulate the cell’s main metabolic and transport processes. These are proteins of the receptor system, vesicular transport, and extracellular matrix, which mainly carry out catabolic processes. The proteins of patients with schizotypal disorder mostly coincided with the classes of other patients, apart from chaperone proteins, which were not found in other studied groups. These proteins are mainly involved in anabolic processes. The main classes of proteins found in patients with APPD are responsible for the metabolism of nucleic acids. Active apoptosis processes were also revealed in these patients. These results from our basic knowledge about the molecular mechanisms of the pathogenesis of these disorders.

Ensemble Learning for Higher Diagnostic Precision in Schizophrenia Using Peripheral Blood Gene Expression Profile

“…These results are in accordance with the previous report. 57 The other top biological processes, such as response to stress (GO:0006950) and its child-term cellular response to stimulus (GO:0051716), have not been directly reported in association with schizophrenia before. However, the response to oxidative stress (GO:0006979), a child term of response to stress, has been implicated in the pathogenesis of psychiatric disorders.…”

Ensemble learning for higher diagnostic precision in schizophrenia using peripheral blood gene expression profile

“…Enrichment analysis of these common genes highlighted key pathways such as apoptosis, and natural killer cell mediated cytotoxicity (Figure 3A) which have been known to be dysregulated in SCZ (Yovel et al, 2000; Parellada and Gassó, 2021). The biological processes related to immune function and organonitrogen compound metabolic process have also been associated with SCZ earlier (Van Kesteren et al, 2017; Dmitrieva et al, 2022). In addition to biological processes and pathways we also identified the key regulators (hub genes) of the protein-protein interaction network (Figure 3B).…”

Идентификация Биомаркеров Шизофрении С Помощью Методов Масс-Спектрометрии (Обзор Литературы)

“…Согласно результатам MS-анализа, в сыворотке больных шизофренией обнаруживаются белки, отсутствующие у здоровых из группы сравнения: тирозинкиназа (активность которой повышается при окислительном стрессе при активации ряда сигнальных путей), белок LANCL1 с неизвестной функцией, ядерный клеточно-специфичный эпителиальный гаплоидный белок, цинк-связывающий белок (747-20597 Да) и гипотетический белок DP1 участка Рolyposis coli (21135 Да) [21]. В недавнем исследовании методами масс-спектрометрии идентифицировали белки сыворотки крови при разных формах шизофрении: для параноидной шизофрении характерны белки, отвечающие за трансляцию и транскрипцию, в то время как значительная часть белков, характерных для простой шизофрении, регулирует основные метаболические и транспортные процессы клетки; это белки рецепторной системы, везикулярного транспорта и внеклеточного матрикса, осуществляющие преимущественно катаболические процессы [22].…”