Proteomic mapping of macrophages in response to the clearance of apoptotic cells reveals a unique reprogramming profile
Benjamin Bernard Armando Raymond,
Andrew Michael Frey,
Matthias Trost
Abstract:During the daily process of healthy cellular turnover, billions of cells undergo apoptosis in the human body. These cells are removed by phagocytic cells, namely macrophages through a process known as efferocytosis, which triggers a cascade of reprogramming events in the cell, with a shift towards a pro-resolving or ‘wound healing’ phenotype. To date, no study has attempted to investigate these phenotypic changes from a proteomic perspective. Here, we present a novel and robust workflow for the investigation o… Show more
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