Proteomic level changes associated with S3I201 treated U87 glioma cells

Jain, Rekha; Atak, Apurva; Yeola, Avani; Srivastava, Sanjeeva

doi:10.1016/j.jprot.2016.08.011

Cited by 5 publications

(1 citation statement)

References 42 publications

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“…Interference with fibronectin decreased the invasive potential of prostate cancer cell lines, similarly to AUY922. Jain et al . investigated changes in the proteome of U87 glioma cells after treatment with S3I201 (STAT3 inhibitor) using 2D gel electrophoresis and iTRAQ, resulting in identification of six differentially expressed protein spots between treated and untreated cells.…”

Section: Profiling Drug Effects On Proteomementioning

confidence: 99%

Proteomics in Drug Development: The Dawn of a New Era?

Frantzi

Latosinska

Mischak

2019

Proteomics Clinical Apps

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Mass spectrometry offers the potential of acquiring high resolution data depicting the functional status of a group of healthy or diseased individuals, according to different conditions. As most of the drugs are currently targeting proteins, proteomics has a dual value, both in the discovery of new molecules as therapeutic targets, but also as a methodology to perform high throughput drug profiling. As there is an evident need for drugs to be improved in terms of efficacy, a mechanistic insight for downstream effectors can be valuable in order to predict side effects and resistance mechanisms. Recently developed assays, like thermal proteome profiling enables comprehensive drug target profiling and is, therefore, of high value in drug discovery. In this review, a systematic literature search is conducted and the most prominent proteomics studies as implicated in assisting drug discovery and development is presented. Focus is placed on investigations that are closer to implementation, therefore particular emphasis is given in studies conducted in human diseased population and further verified in vitro or in vivo.

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Section: Profiling Drug Effects On Proteomementioning

confidence: 99%