Proteomic insight into the venom composition of the largest European rear-fanged snake, Malpolon monspessulanus monspessulanus

Koua, Dominique; Ebou, Anicet; Habbouche, Zeinab; Ballouard, Jean-Marie; Caron, Sébastien; Bonnet, Xavier; Dutertre, Sébastien

doi:10.1016/j.toxcx.2022.100130

Cited by 9 publications

(3 citation statements)

References 31 publications

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“…Two non-front-fanged colubroid (NFFC) snakes of the family Psammophiidae, Malpolon monspessulanus and Malpolon insignitus , can also be found in Italy (with a national distribution limited to the central-western Liguria and the island of Lampedusa, respectively—see [ 76 , 77 ]). These two species are generally believed to induce only mild, local envenomation symptoms, although some reports indicating more severe symptoms exist [ 15 , 78 , 79 , 80 , 81 ]. Two additional species of NFFC venomous snakes, namely Telescopus fallax and Macroprotodon cucullatus , can also be found in Italy, but there are currently no official reports of envenomation caused by them in humans [ 82 ].…”

Section: Results—clinical Management Of Vipera Env...mentioning

confidence: 99%

A Guide to the Clinical Management of Vipera Snakebite in Italy

Di Nicola,

Crevani,

Avella

et al. 2024

Toxins

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The genus Vipera encompasses most species of medically significant venomous snakes of Europe, with Italy harbouring four of them. Envenomation by European vipers can result in severe consequences, but underreporting and the absence of standardised clinical protocols hinder effective snakebite management. This study provides an updated, detailed set of guidelines for the management and treatment of Vipera snakebite tailored for Italian clinicians. It includes taxonomic keys for snake identification, insights into viper venom composition, and recommendations for clinical management. Emphasis is placed on quick and reliable identification of medically relevant snake species, along with appropriate first aid measures. Criteria for antivenom administration are outlined, as well as indications on managing potential side effects. While the protocol is specific to Italy, its methodology can potentially be adapted for other European countries, depending on local resources. The promotion of comprehensive data collection and collaboration among Poison Control Centres is advocated to optimise envenomation management protocols and improve the reporting of epidemiological data concerning snakebite at the country level.

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Section: Results—clinical Management Of Vipera Env...mentioning

confidence: 99%

A Guide to the Clinical Management of Vipera Snakebite in Italy

Di Nicola,

Crevani,

Avella

et al. 2024

Toxins

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“…In case of a prolonged bite, local symptoms involving the bitten area are erythema, edema and pain. Systemic symptoms, including neurotoxic effects (e.g., oculomotor paralysis), have sometimes been reported following Malpolon envenomations [ 30 , 31 , 59 ].…”

Section: Resultsmentioning

confidence: 99%

“…venom is partially unknown. To date, snake venom metalloproteinases, peptidase M1 and cysteine-rich secretory proteins are thought to be its most prominent components [ 30 , 31 , 59 ].…”

Section: Resultsmentioning

confidence: 99%

Venomous Bites, Stings and Poisoning by European Vertebrates as an Overlooked and Emerging Medical Problem: Recognition, Clinical Aspects and Therapeutic Management

Paolino

Nicola

Avella

et al. 2023

Life

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Europe presents a high number of venomous and poisonous animals able to elicit medically relevant symptoms in humans. However, since most of the accidents involving venomous or poisonous animals in Europe are unreported, their incidence and morbidity are severely overlooked. Here we provide an overview of the European vertebrate species of greatest toxicological interest, the clinical manifestations their toxins can cause, and their treatment. We report the clinical symptoms induced by envenomations and poisoning caused by reptiles, fishes, amphibians and mammals in Europe, ranging from mild, local symptoms (e.g., erythema, edema) to systemic and potentially deadly. The present work constitutes a tool for physicians to recognize envenomation/poisoning symptoms caused by the most medically relevant European vertebrates and to decide which approach is the most appropriate to treat them.

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