Proteomic as an Exploratory Approach to Develop Vaccines Against Tick-Borne Diseases Using Lyme Borreliosis as a Test Case

Talagrand-Reboul, Émilie; Westermann, Benoît; Raess, Matthieu A.; Schnell, Gilles; Cantero, Paola; Barthel, Cathy; Ehret‐Sabatier, Laurence; Jaulhac, B.; Boulanger, Nathalie

doi:10.3390/vaccines8030463

Cited by 8 publications

(4 citation statements)

References 64 publications

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“…Antibody to OspC develops early and can be detected in the serum of mice within two weeks of syringe inoculation of B. burgdorferi (Oliver Jr et al, 2016). Consistent with this, nontargeted mass spectrometry of skin biopsies collected from mice seven days after delivery of B. burgdorferi by syringe inoculation also identified OspC as one of the most frequently detected B. burgdorferi proteins (Talagrand-Reboul et al, 2020).…”

Section: Outer Surface Protein C (Ospc) Expression Structure and Functionsupporting

confidence: 59%

Human and Veterinary Vaccines for Lyme Disease

O’Bier¹,

Hatke²,

Camire³

et al. 2022

Current Issues in Molecular Biology

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Lyme disease (LD) is an emerging zoonotic infection that is increasing in incidence in North America, Europe, and Asia. With the development of safe and efficacious vaccines, LD can potentially be prevented. Vaccination offers a cost-effective and safe approach for decreasing the risk of infection. While LD vaccines have been widely used in veterinary medicine, they are not available as a preventive tool for humans. Central to the d e v e l o p m e n t o f e f f e c t i v e v a c c i n e s i s a n understanding of the enzootic cycle of LD, differential gene expression of Borrelia burgdorferi in response to environmental variables, and the genetic and antigenic diversity of the unique bacteria that cause this debilitating disease. Here we review these areas as they pertain to past and present efforts to develop human, veterinary, and reservoir targeting LD vaccines. In addition, we offer a brief overview of additional preventative measures that should employed in conjunction with vaccination.

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Section: Outer Surface Protein C (Ospc) Expression Structure and Functionsupporting

confidence: 59%

Human and Veterinary Vaccines for Lyme Disease

O’Bier¹,

Hatke²,

Camire³

et al. 2022

Current Issues in Molecular Biology

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“…It might be used to identify tick saliva proteins inoculated into the host skin. Targeted proteomics will be also very useful to identify vaccine candidates (325). To develop effective vaccines against VBDs, after identification of good vaccine candidates, efficient delivery system will be necessary in the future to take into consideration the skin microbiome and the skin immunity (326).…”

Section: Discussionmentioning

confidence: 99%

Induced Transient Immune Tolerance in Ticks and Vertebrate Host: A Keystone of Tick-Borne Diseases?

Boulanger

Wikel

2021

Front. Immunol.

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Ticks and tick transmitted infectious agents are increasing global public health threats due to increasing abundance, expanding geographic ranges of vectors and pathogens, and emerging tick-borne infectious agents. Greater understanding of tick, host, and pathogen interactions will contribute to development of novel tick control and disease prevention strategies. Tick-borne pathogens adapt in multiple ways to very different tick and vertebrate host environments and defenses. Ticks effectively pharmacomodulate by its saliva host innate and adaptive immune defenses. In this review, we examine the idea that successful synergy between tick and tick-borne pathogen results in host immune tolerance that facilitates successful tick infection and feeding, creates a favorable site for pathogen introduction, modulates cutaneous and systemic immune defenses to establish infection, and contributes to successful long-term infection. Tick, host, and pathogen elements examined here include interaction of tick innate immunity and microbiome with tick-borne pathogens; tick modulation of host cutaneous defenses prior to pathogen transmission; how tick and pathogen target vertebrate host defenses that lead to different modes of interaction and host infection status (reservoir, incompetent, resistant, clinically ill); tick saliva bioactive molecules as important factors in determining those pathogens for which the tick is a competent vector; and, the need for translational studies to advance this field of study. Gaps in our understanding of these relationships are identified, that if successfully addressed, can advance the development of strategies to successfully disrupt both tick feeding and pathogen transmission.

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“…Nevertheless, advanced mass spectrometry-based proteomics provide unmatched information such as protein identification, quantification and post-translational modifications. The characterization of the Bb proteome enables basic science research and the development of vaccines and diagnostics (44,165). Though several proteomic studies have been published, no highresolution mass spectrometry (MS) data is represented in a publicly accessible repository for the community to access and utilize in research goals (162,166,167).…”

Section: Proteomic Insights From Borreliaceae Lineagesmentioning

confidence: 99%

Recent Progress in Lyme Disease and Remaining Challenges

Bobe

Jutras

Horn³

et al. 2021

Front. Med.

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Lyme disease (also known as Lyme borreliosis) is the most common vector-borne disease in the United States with an estimated 476,000 cases per year. While historically, the long-term impact of Lyme disease on patients has been controversial, mounting evidence supports the idea that a substantial number of patients experience persistent symptoms following treatment. The research community has largely lacked the necessary funding to properly advance the scientific and clinical understanding of the disease, or to develop and evaluate innovative approaches for prevention, diagnosis, and treatment. Given the many outstanding questions raised into the diagnosis, clinical presentation and treatment of Lyme disease, and the underlying molecular mechanisms that trigger persistent disease, there is an urgent need for more support. This review article summarizes progress over the past 5 years in our understanding of Lyme and tick-borne diseases in the United States and highlights remaining challenges.

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Proteomic as an Exploratory Approach to Develop Vaccines Against Tick-Borne Diseases Using Lyme Borreliosis as a Test Case

Cited by 8 publications

References 64 publications

Human and Veterinary Vaccines for Lyme Disease

Human and Veterinary Vaccines for Lyme Disease

Induced Transient Immune Tolerance in Ticks and Vertebrate Host: A Keystone of Tick-Borne Diseases?

Recent Progress in Lyme Disease and Remaining Challenges

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