Proteomic and genomic analyses suggest the association of apolipoprotein C1 with abdominal aortic aneurysm

Abstract

ApoC1 may be a novel biomarker for AAA.

Biomarkers for AAA: Encouraging steps but clinical relevance still to be delivered

“…Another interesting point Moxon et al noted in their study was that despite the proteins predicted to be secreted from human and mice AAA in Gene Ontology annotations mediating related processes, few common candidates were found . This highlights the obvious but sometimes neglected fact that the potential biomarkers identified in laboratory bench studies (AAA artificially created in mice in this case) are not always applicable to bed‐side clinical medicine.…”

Protective role of the matricellular protein CCN3 in abdominal aortic aneurysm

“…The authors analyzed CCN3 expression in human samples with AAA, but primarily made use of animal models of AAA and previously generated CCN3-deficient mice. In these mice that develop normally when unchallenged (11), they employed two established murine in vivo models of aortic aneurism-elastase perfusion (15) and angiotensin II (Ang II) infusion (16)(17)(18). Transient elastase perfusion of the mouse aorta results in partial degradation of the aortic elastin and an associated transmural mononuclear inflammatory response, which leads to a feed-forward cycle increasing local production of several elastolytic MMPs, thereby resulting in destruction of the elastic lamellae, and subsequent aneurysm development (15).…”

“…The high levels of Ang II found in human AAA lesions (19) form a conceptual base of the Ang II infusion model used in this study. This model is known to elicit, in mice, AAAs mimicking features of human AAA, including dramatic aortic dilation, aortic media destruction, and inflammatory cell infiltration as well as ROS and MMP expression (18).…”

The Need for Translational Research to Advance Peripheral Artery Disease Management

“…Limited access to arterial biopsies from patients and suitable controls presents a significant hurdle to PAD research [11]. This has in part been addressed through the development of rodent models for PAD which have been widely employed in the literature, although their relevance and translational potential to the clinical situation is not always immediately clear [12]. This is highlighted by Lin and colleagues who provide an excellent overview of widely used PAD models, and discuss the role of imaging techniques to provide data on PAD formation and progression in experimental animals [13].…”

“…For example, recent advances in molecular and biochemical techniques permit elaborate analyses which yield large biological datasets, but are typically limited to relatively small sample sizes due to technical and financial restrictions. In such studies, identifying relevant outcomes from complex data can be challenging, and the generalizability of findings to the wider PAD patient population is not immediately apparent when these approaches are applied in isolation [12,32]. We therefore strongly believe that multi-disciplinary studies collaboratively conducted by laboratory scientists, clinicians and patients are vital to advance our understanding, and ultimately the management of PAD.…”