Proteomic analysis of short- and intermediate-term memory in Hermissenda

Crow, Terry; Xue-Bian, Juan-Juan

doi:10.1016/j.neuroscience.2011.06.063

Cited by 6 publications

(3 citation statements)

References 82 publications

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“…We show here that the two lapses observed in our experiments coincide with the periods when there is a change in molecular mechanisms only at the early stages of memory formation. So it seems that recall of memory becomes more difficult when there are changes in molecular dependencies indicating that distinct molecular pathways are responsible for the different phases of memory formation3334.…”

Section: Discussionmentioning

confidence: 99%

Susceptibility of memory consolidation during lapses in recall

et al. 2013

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Memories that can be recalled several hours after learning may paradoxically become inaccessible for brief periods after their formation. This raises major questions about the function of these early memory lapses in the structure of memory consolidation. These questions are difficult to investigate because of the lack of information on the precise timing of lapses. However, the use of a single-trial conditioning paradigm in Lymnaea solves this problem. Here we use electrophysiological and behavioural experiments to reveal lapses in memory recall at 30 min and 2 h post conditioning. We show that only during these lapses is consolidation of long-term memory susceptible to interruption by external disturbance. These shared time points of memory lapse and susceptibility correspond to transitions between different phases of memory that have different molecular requirements. We propose that during periods of molecular transition memory recall is weakened, allowing novel sensory cues to block the consolidation of long-term memory.

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Section: Discussionmentioning

confidence: 99%

Susceptibility of memory consolidation during lapses in recall

et al. 2013

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“…Significant protein regulation was detected at 30 min and 3 h post-conditioning. These proteins were involved in diverse cellular functions, such as translational regulation, cell signaling, cytoskeletal regulation, metabolic activity, and protein degradation [68]. In the Aplysia studies, memory at the behavioral level and its synaptic correlates were not observable at various times after training [69,70].…”

Section: Discussionmentioning

confidence: 99%

Critical Period of Memory Enhancement during Taste Avoidance Conditioning in Lymnaea stagnalis

et al. 2013

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The present study investigated the optimal training procedure leading to long-lasting taste avoidance behavior in Lymnaea. A training procedure comprising 5 repeated pairings of a conditional stimulus (CS, sucrose), with an unconditional stimulus (US, a tactile stimulation to the animal’s head), over a 4-day period resulted in an enhanced memory formation than 10 CS-US repeated pairings over a 2-day period or 20 CS-US repeated pairings on a single day. Backward conditioning (US-CS) pairings did not result in conditioning. Thus, this taste avoidance conditioning was CS-US pairing specific. Food avoidance behavior was not observed following training, however, if snails were immediately subjected to a cold-block (4°C for 10 min). It was critical that the cold-block be applied within 10 min to block long-term memory (LTM) formation. Further, exposure to the cold-block 180 min after training also blocked both STM and LTM formation. The effects of the cold-block on subsequent learning and memory formation were also examined. We found no long lasting effects of the cold-block on subsequent memory formation. If protein kinase C was activated before the conditioning paradigm, snails could still acquire STM despite exposure to the cold-block.

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“…Previous studies have already explored memory processes through the prism of proteomics. Both invertebrate (Crow & Xue‐Bian, ; Monje et al ., ) and vertebrate models (Henninger et al ., ; Li et al ., ; Monopoli et al ., ; Kähne et al ., ; Hong et al ., ; Rao‐Ruiz et al ., ; Smidak et al ., ) were investigated. Smidak et al .…”

Section: Introductionmentioning

confidence: 99%

A proteomic analysis of contextual fear conditioned rats reveals dynamic modifications in neuron and oligodendrocyte protein expression in the dentate gyrus

Houyoux

Wattiez

Ris

2017

Eur J of Neuroscience

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Contextual memory is an intricate process involving synaptic plasticity and network rearrangement. Both are governed by many molecular processes including phosphorylation and modulation of protein expression. However, little is known about the molecules involved in it. Here, we exploited the advantages of a quantitative proteomic approach to identify a great number of molecules in the rat dentate gyrus after a contextual fear conditioning session. Our results allowed us to highlight protein expression patterns, not only related to neuroplasticity, but also to myelin structure, such as myelin basic protein and myelin proteolipid protein showing a decrease in expression. Validation of the modification in protein expression reveals a dynamic profile during the 48 h following the fear conditioning session. The expression of proteins involved in neurite outgrowth, such as BASP-1 and calcineurin B1, and in synaptic structure and function, VAMP2 and RAB3C, was increased in the dentate gyrus of rats submitted to fear conditioning compared to controls. We showed that the increase in BASP-1 protein was specific to fear conditioning learning as it was not present in immediate-shock rats, neither in rats exposed to a novel environment without being shocked. As myelin is known to stabilise synaptic network, the decrease in myelin proteins suggests a neuroglia interactive process taking place in the dentate gyrus in the 24 h following contextual fear learning, which has never been demonstrated before. These results therefore open the way to the study of new plasticity mechanisms underlying learning and memory.

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Proteomic analysis of short- and intermediate-term memory in Hermissenda

Cited by 6 publications

References 82 publications

Susceptibility of memory consolidation during lapses in recall

Susceptibility of memory consolidation during lapses in recall

Critical Period of Memory Enhancement during Taste Avoidance Conditioning in Lymnaea stagnalis

A proteomic analysis of contextual fear conditioned rats reveals dynamic modifications in neuron and oligodendrocyte protein expression in the dentate gyrus

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