Proteomic analysis of protein expression in human tonsillar cancer differentially expressed proteins characterize human tonsillar cancer

Roblick, Uwe J.; Bader, Franz G.; Hammarstedt, Lalle; Habermann, Jens K.; Hellman, Ulf; Becker, Susanne; Sundmäcker, Axel; Gemoll, Timo; Zimmermann, K.; Auer, Gert; Munck‐Wikland, Eva

doi:10.1080/02841860802314696

Cited by 3 publications

(1 citation statement)

References 35 publications

(40 reference statements)

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“…Proteomic analysis has been used recently in the field of human clinical science such as the identification of markers for the diagnosis and/or prognosis of various malignancies [29][30][31][32]. To our knowledge, however, proteomic analysis of human bile has not yet been reported except in a limited number of studies [33,34].…”

Section: Discussionmentioning

confidence: 99%

Significance of Alanine Aminopeptidase N (APN) in Bile in the Diagnosis of Acute Cellular Rejection After Liver Transplantation

Kim¹,

Aono²,

Marubashi³

et al. 2012

Journal of Surgical Research

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Section: Discussionmentioning

confidence: 99%

Significance of Alanine Aminopeptidase N (APN) in Bile in the Diagnosis of Acute Cellular Rejection After Liver Transplantation

Kim¹,

Aono²,

Marubashi³

et al. 2012

Journal of Surgical Research

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A Multifunctional LNA Oligonucleotide-Based Strategy Blocks AR Expression and Transactivation Activity in PCa Cells

Castanotto

Zhang

Rüger

et al. 2021

Molecular Therapy - Nucleic Acids

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The androgen receptor (AR) plays a critical role in the development of prostate cancer (PCa) through the activation of androgen-induced cellular proliferation genes. Thus, blocking AR-mediated transcriptional activation is expected to inhibit the growth and spread of PCa. Using tailor-made splice-switching locked nucleic acid (LNA) oligonucleotides (SSOs), we successfully redirected splicing of the AR precursor (pre-)mRNA and destabilized the transcripts via the introduction of premature stop codons. Furthermore, the SSOs simultaneously favored production of the AR45 mRNA in lieu of the full-length AR. AR45 is an AR isoform that can attenuate the activity of both full-length and oncogenic forms of AR by binding to their common N-terminal domain (NTD), thereby blocking their transactivation potential. A large screen was subsequently used to identify individual SSOs that could best perform this dual function. The selected SSOs powerfully silence AR expression and modulate the expression of AR-responsive cellular genes. This bi-functional strategy that uses a single therapeutic molecule can be the basis for novel PCa treatments. It might also be customized to other types of therapies that require the silencing of one gene and the simultaneous expression of a different isoform.

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Anatomical pathology is dead? Long live anatomical pathology

Nicholls

Francis

2011

Pathology

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Proteomic analysis of protein expression in human tonsillar cancer differentially expressed proteins characterize human tonsillar cancer

Cited by 3 publications

References 35 publications

Significance of Alanine Aminopeptidase N (APN) in Bile in the Diagnosis of Acute Cellular Rejection After Liver Transplantation

Significance of Alanine Aminopeptidase N (APN) in Bile in the Diagnosis of Acute Cellular Rejection After Liver Transplantation

A Multifunctional LNA Oligonucleotide-Based Strategy Blocks AR Expression and Transactivation Activity in PCa Cells

Anatomical pathology is dead? Long live anatomical pathology

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