“…For proteome analysis, according to different strategies, i.e., top-down and bottom-up, MD separation could be performed in a variety of modes. − Furthermore, integrated platforms with the combination of on-line sample pretreatment, separation, and identification have also been developed. − Following the typical overview of the above-mentioned MD separation modes for proteome analysis, illustrated in Figure , this Review will summarize the recent advances of such techniques, together with their applications in proteomic study over the past 2 years.…”