Proteomic analysis of cardiorespiratory fitness for prediction of mortality and multisystem disease risks
Andrew S. Perry,
Eric Farber-Eger,
Tomas Gonzales
et al.
Abstract:Despite the wide effects of cardiorespiratory fitness (CRF) on metabolic, cardiovascular, pulmonary and neurological health, challenges in the feasibility and reproducibility of CRF measurements have impeded its use for clinical decision-making. Here we link proteomic profiles to CRF in 14,145 individuals across four international cohorts with diverse CRF ascertainment methods to establish, validate and characterize a proteomic CRF score. In a cohort of around 22,000 individuals in the UK Biobank, a proteomic … Show more
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