Proteomic analysis of antiviral innate immunity

Albarnaz, Jonas D.; Weekes, Michael P.

doi:10.1016/j.coviro.2022.101291

Cited by 2 publications

(1 citation statement)

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“…The functional proteome undergoes dynamic changes in response to various stimuli or physiological conditions, for instance, upon exposure to the pathogen. The dynamic changes include up‐ or down‐regulation of different proteins involved in immune defence mechanisms, stress responses and inflammation, as well as the modulation of proteins associated with antigen presentation (Albarnaz & Weekes, 2023; Gajahin Gamage et al., 2022; Kruse et al., 2017). Through comparative proteome analysis, the functional proteome changes upon infection in both disease‐resistant and disease‐susceptible phenotypes could be identified.…”

Section: Introductionmentioning

confidence: 99%

Comparative proteome analysis revealed potential biomarkers and the underlying immune mechanisms in Vibrio‐resistant hybrid grouper, Epinephelus fuscoguttatus ♀ × Epinephelus lanceolatus ♂

Abu Aziz,

Christianus,

Wan Solahudin

et al. 2024

Journal of Fish Diseases

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Vibrio alginolyticus is the causative agent of vibriosis, a common bacterial infection in grouper aquaculture that is associated with the development of haemorrhagic and non‐haemorrhagic ulcerations on the fish. In the present study, comparative proteome analysis was performed on serum samples from Vibrio‐resistant and Vibrio‐susceptible grouper. Samples were analysed using high‐throughput LC‐MS/MS and identified 2770 unique peptides that corresponded to 344 proteins. Subsequent analysis identified 21 proteins that were significantly up‐regulated in the resistant group compared to the control and the susceptible groups. Those proteins are associated with immunostimulatory effects, signalling and binding cascade, metabolism, and maintaining tissue integrity and physiological condition. Besides, potential protein biomarkers related to the immune system were identified, which could be associated with the disease‐resistant phenotype. These data provide insights into the underlying immune mechanism of hybrid groupers upon Vibrio sp. infection.

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Section: Introductionmentioning

confidence: 99%