Proteomic analysis for anti-atherosclerotic effect of tetrahydroxystilbene glucoside in rats

Tetrahydroxystilbene Glucoside Protects Against Oxidized LDL-Induced Endothelial Dysfunction via Regulating Vimentin Cytoskeleton and its Colocalization with ICAM-1 and VCAM-1

“…Vimentin has been proved to be required for cell apopotosis and adhesion, and it is a possible molecular target responsible for atherogenesis suppression induced by TSG treatment [14,16,24]. Therefore, we examined the effects of TSG on vimentin expression and cleavage in oxLDL-induced HUVECs.…”

“…Our recent studies have shown that vimentin is one of the key proteins responsible for atherogenesis suppression induced by TSG treatment [14]. Vimentin is a member of the intermediate filament protein family and has been shown to be present in cells of the blood vessel walls.…”

Potential Application of Tetrahydroxystilbene Glucoside in Treatment of Alzheimer’s Disease

“…Recent progresses suggested that TSG might have much pharmacological properties including antioxidant, anti-aging, antiinflammation, anti-atherosclerosis, anti-hyperlipidaemia, anti-platelet activity, ameliorate diabetic nephropathy, neuroprotection, hair growth, and cardioprotective effects [47][48][49][50][51][52][53][54][55][56][57][58] . There are increasing reports about the roles of TSG on learning and memory changes of animal AD models, as well as possible action mechanisms.…”

Isolation of biosynthesis related transcripts of 2,3,5,4'-tetrahydroxy stilbene-2-O-β-D-glucoside from Fallopia multiflora by suppression subtractive hybridization

“…2,3,5,4'-tetrahydroxy stilbene-2-O-ß-Dglucoside (THSG) is an active component in F. multiflora, which possesses anti-hyperlipidemic [4], anti-oxidative, anti-inflammatory, endothelial-protective activities [5]. Furthermore, THSG can protect osteoblastic MC3T3-E1 cells via inhibiting the release of bone-resorbing mediators and oxidative damage of the cells [6], and suppress atherosclerosis by altering the expression of key proteins that may be novel molecular targets responsible for atherogenesis [7]. Sun et al who reported that THSG might provide a potentially new strategy for preventing and treating neurodegenerative disorders such as Parkinson's disease, also showed that THSG may protect neurons against MPP+-induced cell death through improving mitochondrial function, decreasing oxidative stress and inhibiting apoptosis [8].…”