Proteome-scale tissue mapping using mass spectrometry based on label-free and multiplexed workflows
Yumi Kwon,
Jongmin Woo,
Fengchao Yu
et al.
Abstract:Multiplexed bimolecular profiling of tissue microenvironment, or spatial omics, can provide deep insight into cellular compositions and interactions in both normal and diseased tissues. Proteome-scale tissue mapping, which aims to unbiasedly visualize all the proteins in whole tissue section or region of interest, has attracted significant interest because it holds great potential to directly reveal diagnostic biomarkers and therapeutic targets. While many approaches are available, however, proteome mapping st… Show more
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