Proteome response of dental pulp cells to exogenous FGF8

Tsikandelova, Rozaliya; Mladenov, Petko; Planchon, Sébastien; Kalenderova, Silvia; Praskova, Maria; Mihaylova, Zornitsa; Stanimirov, Pavel; Mitev, Vanio; Renaut, Jenny; Ishkitiev, Nikolay

doi:10.1016/j.jprot.2018.05.004

Cited by 14 publications

(6 citation statements)

References 66 publications

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“…[173,174] FGF8, a member of the paracrine-acting FGF family, has been shown to orchestrate the migration, proliferation, and differentiation of dental pulp stem cells. [175] FGF8 has the potential to induce the earliest dental markers such as Lhx6 and Lhx7. [176] Recently, it was reported that early delivery of exogenous FGF2 to dental pulp resulted in accelerated odontoblast differentiation.…”

Section: Delivery Of Growth Factorsmentioning

confidence: 99%

Drug Delivery (Nano)Platforms for Oral and Dental Applications: Tissue Regeneration, Infection Control, and Cancer Management

et al. 2021

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The oral cavity and oropharynx are complex environments that are susceptible to physical, chemical, and microbiological insults. They are also common sites for pathological and cancerous changes. The effectiveness of conventional locally-administered medications against diseases affecting these oral milieus may be compromised by constant salivary flow. For systemically-administered medications, drug resistance and adverse side-effects are issues that need to be resolved. New strategies for drug delivery have been investigated over the last decade to overcome these obstacles. Synthesis of nanoparticle-containing agents that promote healing represents a quantum leap in ensuring safe, efficient drug delivery to the affected tissues. Micro/nanoencapsulants with unique structures and properties function as more favorable drug-release platforms than conventional treatment approaches. The present review provides an overview of newly-developed nanocarriers and discusses their potential applications and limitations in various fields of dentistry and oral medicine.

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Section: Delivery Of Growth Factorsmentioning

confidence: 99%

Drug Delivery (Nano)Platforms for Oral and Dental Applications: Tissue Regeneration, Infection Control, and Cancer Management

et al. 2021

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“…Tsikandelova et al[ 46 ] studied the effect of fibroblastic growth factor-8 (FGF-8) on adult heterogeneous DPSCs by assessing their genetic, proteomic, proliferative and mineralization profiles. Enhanced proliferation of DPSCs was noted after short-term exposure to FGF-8.…”

Section: Discussionmentioning

confidence: 99%

Proteomic profiling of various human dental stem cells - a systematic review

Hosmani

Assiri

Almubarak

et al. 2020

WJSC

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BACKGROUND The proteomic signature or profile best describes the functional component of a cell during its routine metabolic and survival activities. Additional complexity in differentiation and maturation is observed in stem/progenitor cells. The role of functional proteins at the cellular level has long been attributed to anatomical niches, and stem cells do not deflect from this attribution. Human dental stem cells (hDSCs), on the whole, are a combination of mesenchymal and epithelial coordinates observed throughout craniofacial bones to pulp. AIM To specify the proteomic profile and compare each type of hDSC with other mesenchymal stem cells (MSCs) of various niches. Furthermore, we analyzed the characteristics of the microenvironment and preconditioning changes associated with the proteomic profile of hDSCs and their influence on committed lineage differentiation. METHODS Literature searches were performed in PubMed, EMBASE, Scopus, and Web of Science databases, from January 1990 to December 2018. An extra inquiry of the grey literature was completed on Google Scholar, ProQuest, and OpenGrey. Relevant MeSH terms (PubMed) and keywords related to dental stem cells were used independently and in combination. RESULTS The initial search resulted in 134 articles. Of the 134 full-texts assessed, 96 articles were excluded and 38 articles that met the eligibility criteria were reviewed. The overall assessment of hDSCs and other MSCs suggests that differences in the proteomic profile can be due to stem cellular complexity acquired from varied tissue sources during embryonic development. However, our comparison of the proteomic profile suffered inconsistencies due to the heterogeneity of various hDSCs. We believe that the existence of a heterogeneous population of stem cells at a given niche determines the modalities of regeneration or tissue repair. Added prominences to the differences present between various hDSCs have been reasoned out. CONCLUSION Systematic review on proteomic studies of various hDSCs are promising as an eye-opener for revisiting the proteomic profile and in-depth analysis to elucidate more refined mechanisms of hDSC functionalities.

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“…In the absence of FGF8, Pitx2 expression in the oral epithelium is diminished, thereby affecting tooth development (43,44). In addition, by activating the dental mesenchymal markers Barx1 and Pax9 in the mesenchyme, the coordination of FGF8 and BMP4 signaling pathways determines not only the proto-molar or proto-incisor fate of mandibular mesenchymal cells, but also the tooth emergence sites by regulating the migration of the tooth germinal cells (37,42,45). Conditional FGF8 gene knockout in the ectoderm leads to significantly decreased expression of Barx1 and Pax9 in the presumptive molar region, and thus molar teeth are not formed and rudimentary incisors develop instead (37,(46)(47)(48)(49)(50)(51)(52).…”

Section: Fgf8 Subfamily Members In Craniofacial Developmentmentioning

confidence: 99%

Roles of FGF8 subfamily in embryogenesis and oral‑maxillofacial diseases (Review)

et al. 2019

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Fibroblast growth factors (FGFs) are diffusible polypeptides released by a variety of cell types. FGF8 subfamily members regulate embryonic development processes through controlling progenitor cell growth and differentiation, and are also functional in adults in tissue repair to maintain tissue homeostasis. FGF8 family members exhibit unique binding affinities with FGF receptors and tissue distribution patterns. Increasing evidence suggests that, by regulating multiple cellular signaling pathways, alterations in the FGF8 subfamily are involved in craniofacial development, odontogenesis, tongue development and salivary gland branching morphogenesis. Aberrant FGF signaling transduction, caused by mutations as well as abnormal expression or isoform splicing, plays an important role in the development of oral diseases. Targeting FGF8 subfamily members provides a new promising strategy for the treatment of oral diseases. The aim of this review was to summarize the aberrant regulations of FGF8 subfamily members and their potential implications in oral-maxillofacial diseases. Contents

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Proteome response of dental pulp cells to exogenous FGF8

Cited by 14 publications

References 66 publications

Drug Delivery (Nano)Platforms for Oral and Dental Applications: Tissue Regeneration, Infection Control, and Cancer Management

Drug Delivery (Nano)Platforms for Oral and Dental Applications: Tissue Regeneration, Infection Control, and Cancer Management

Proteomic profiling of various human dental stem cells - a systematic review

Roles of FGF8 subfamily in embryogenesis and oral‑maxillofacial diseases (Review)

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