Proteome Analysis of Outer Membrane and Extracellular Proteins from
            <i>Pseudomonas aeruginosa</i>
            for Vaccine Discovery

Cordwell, Stuart J.; Nouwens, Amanda

doi:10.1002/0470012536.ch13

Cited by 1 publication

(1 citation statement)

References 39 publications

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“…In general, bacterial membrane proteins such as TAAs perform numerous important functions in pathogenesis, of which the first interaction with the extracellular environment in the mammalian host is of crucial importance. The extent of virulence of pathogenic organisms depends on various characteristics of both the organism itself (i.e., capacity of entering, infiltrating, and spreading through the host) and the host defence (i.e., immune status and metabolic conditions) [20][21][22]. It has become evident that TAAs play a prominent role in bacterial pathogenicity, where quick adaptation to changing conditions is crucial.…”

Section: Introductionmentioning

confidence: 99%

Immunogenicity of trimeric autotransporter adhesins and their potential as vaccine targets

Thibau

Dichter

Vaca

et al. 2019

Med Microbiol Immunol

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The current problem of increasing antibiotic resistance and the resurgence of numerous infections indicate the need for novel vaccination strategies more than ever. In vaccine development, the search for and the selection of adequate vaccine antigens is the first important step. In recent years, bacterial outer membrane proteins have become of major interest, as they are the main proteins interacting with the extracellular environment. Trimeric autotransporter adhesins (TAAs) are important virulence factors in many Gram-negative bacteria, are localised on the bacterial surface, and mediate the first adherence to host cells in the course of infection. One example is the Neisseria adhesin A (NadA), which is currently used as a subunit in a licensed vaccine against Neisseria meningitidis. Other TAAs that seem promising vaccine candidates are the Acinetobacter trimeric autotransporter (Ata), the Haemophilus influenzae adhesin (Hia), and TAAs of the genus Bartonella. Here, we review the suitability of various TAAs as vaccine candidates.

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Section: Introductionmentioning

confidence: 99%