2021
DOI: 10.3389/fcvm.2020.594441
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Proteolytic Regulation of the Lectin-Like Oxidized Lipoprotein Receptor LOX-1

Abstract: The lectin-like oxidized-LDL (oxLDL) receptor LOX-1, which is broadly expressed in vascular cells, represents a key mediator of endothelial activation and dysfunction in atherosclerotic plaque development. Being a member of the C-type lectin receptor family, LOX-1 can bind different ligands, with oxLDL being the best characterized. LOX-1 mediates oxLDL uptake into vascular cells and by this means can promote foam cell formation. In addition, LOX-1 triggers multiple signaling pathways, which ultimately induce a… Show more

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Cited by 20 publications
(35 citation statements)
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“…LOX-1 Moreover, the activation of the NF-κB pathway appeared to link specifically oxLDL and LOX-1, as it did not occur in response to nLDL and it did not affect LDLR. The ultimate levels of LOX-1 on cell surfaces can be further controlled by other mechanisms, including microRNAs, proteolysis, and receptor internalization [ 37 ].…”
Section: Discussionmentioning
confidence: 99%
“…LOX-1 Moreover, the activation of the NF-κB pathway appeared to link specifically oxLDL and LOX-1, as it did not occur in response to nLDL and it did not affect LDLR. The ultimate levels of LOX-1 on cell surfaces can be further controlled by other mechanisms, including microRNAs, proteolysis, and receptor internalization [ 37 ].…”
Section: Discussionmentioning
confidence: 99%
“…The analysis revealed also that SR-BI correlates with one more parameter -Lectin-type oxidized LDL receptor 1 (LOX-1). In the latest publications (2020 and 2021), LOX-1 is presented as a promising target for early diagnosis and cardiovascular risk prediction [39][40][41]. Such enthusiastic announcements made us expect to nd higher levels of LOX-1 in people with stroke, after a myocardial infarction or with obesity, but no such association was found in our geriatric population.…”
Section: Discussionmentioning
confidence: 93%
“…The analysis revealed also that SR-BI correlates with one more parameter—Lectin-type oxidized LDL receptor 1. In the latest publications (2020 and 2021), LOX-1 is presented as a promising target for early diagnosis and cardiovascular risk prediction [ 49 , 50 , 51 ]. Such enthusiastic announcements made us expect to find higher levels of LOX-1 in people with stroke, after a myocardial infarction or with obesity, but no such association was found in our geriatric population, perhaps due to a small enough study group or a too-high degree of atherosclerosis in the entire study group.…”
Section: Discussionmentioning
confidence: 99%