Proteolytic host cell enzymes in gingival crevice fluid

Uitto, Veli‐Jukka; Overall, Christopher M.; McCulloch, C

doi:10.1034/j.1600-0757.2003.03106.x

Cited by 207 publications

(251 citation statements)

References 202 publications

(212 reference statements)

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“…Stromelysin‐1 (MMP‐3) is involved in periodontal extracellular matrix processing of the basal membrane as well as the MMP activation cascades (Sorsa et al, 2004; Uitto, Overall, & McCulloch, 2003). Fibroblasts, chondrocytes, and endothelial cells can produce MMP‐3 as a part of inflammatory tissue destruction cascades (Haerian, Adonogianaki, Mooney, Docherty, & Kinane, 1995; Alpagot, Bell, Lundergan, Chambers, & Rudin, 2001; Reynolds, Hembry, & Meikle, 1994).…”

Section: Discussionmentioning

confidence: 99%

Inflammatory mediator polymorphisms associate with initial periodontitis in adolescents

Heikkinen

Kettunen

Kovanen

et al. 2016

Clinical & Exp Dental Res

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Several studies have addressed cytokine gene polymorphisms and their possible associations with periodontitis. We examined the association between salivary anti‐ and pro‐inflammatory mediator polymorphisms and initial periodontitis in Finnish adolescents, taking into account the effect of smoking. Salivary samples of 93 clinically examined adolescents from Eastern Finland were analyzed. Their oral health and smoking habits were recorded. Periodontal probing depth (PPD), and bleeding on probing (BOP) at four sites per tooth, root calculus (RC), and visible plaque index (VPI) were recorded from the index teeth. Salivary MMP‐8 median values were assessed. The sites with ≥4 mm PD were categorized as follows: PPD1 = one or more ≥4 mm pocket, PPD2 = two or more ≥4 mm pockets, and PPD3 = three or more ≥4 mm pockets. Genomic DNA was extracted from 300 μl of the saliva samples by genomic QIAamp® DNA Blood Mini Kit and genotyped for polymorphisms. Genetic variants for genotyping were selected from the following genes of interest: S100A8, FCGR2A, FCGR2B, IL10, MMP8, MMP3, MMP13, VDR, TLR4, MMP2, MPO, ELANE, IL1A, IL1B, IL1RN, CD28, MMP9, DDX39B, NFKBIL1, LTA, TNF, SOD2, IL6, TLR4, TIMP1, and SYN1. After false discovery rate control (FDR), polymorphisms in MMP3 (rs679620, rs520540, rs639752), CD28 (rs3116496), and VDR (rs2228570) associated (FDR q < 0.05) with deepened periodontal pockets. Smoking did not affect the results. Genetic polymorphisms of pro‐inflammatory mediators MMP3, CD28, and VDR seem to link to initial periodontitis.

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Section: Discussionmentioning

confidence: 99%

Inflammatory mediator polymorphisms associate with initial periodontitis in adolescents

Heikkinen

Kettunen

Kovanen

et al. 2016

Clinical & Exp Dental Res

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“…A group of enzymes thought to be important in this degenerative process is the matrix metalloproteinase familly (MMPs) 2,3) . Gingival fibroblasts, keratinocytes, .…”

Section: Introductionmentioning

confidence: 99%

Interrelationship of Matrix Metalloproteinase and TNF-α in Human Gingiva with Chronic Periodontitis associated to Type 2 Diabetes Mellitus

Kim

Park

Shin

et al. 2006

J Korean Acad Periodontol

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“…Bunlar; MMP-1, MMP-2, MMP-8, MMP-9, MMP-12, MMP-13 ve MMP-14'tür. 24 MMP-8, tip 1, 2 ve 3 kollajenlerin hepsini hidrolize etse de tip 1 kollajeni diğerlerine göre daha hızlı yıkıma uğratır ve periodontitisteki yıkımda esas kollajenazdır. MMP-8, kemik iliğindeki PMNL olgunlaşması sırasında sentezlendikten sonra glikozillenir ve spesifik subselüler granüllerde depolanır.…”

Section: Mmp-8 Ve Peri̇odontal Hastalikunclassified

Peri̇odontal Hastaliklarda MMP-8’i̇n Rolü

Uslu¹,

Eltas²

2015

Atatürk Üniversitesi Diş Hekimliği Fakültesi Dergisi

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Proteolytic host cell enzymes in gingival crevice fluid

Cited by 207 publications

References 202 publications

Inflammatory mediator polymorphisms associate with initial periodontitis in adolescents

Inflammatory mediator polymorphisms associate with initial periodontitis in adolescents

Interrelationship of Matrix Metalloproteinase and TNF-α in Human Gingiva with Chronic Periodontitis associated to Type 2 Diabetes Mellitus

Peri̇odontal Hastaliklarda MMP-8’i̇n Rolü

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