Proteolytic detergent enzymes enhance the allergic antibody responses of guinea pigs to nonproteolytic detergent enzymes in a mixture: Implications for occupational exposure☆☆☆★★★

Sarlo, Katherine; Ritz, Harry L.; Fletcher, E. Robert; Schrotel, Karen R.; Clark, Edwin D.

doi:10.1016/s0091-6749(97)70139-8

Cited by 30 publications

(11 citation statements)

References 27 publications

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“…The purchased tonnages of amylase and cellulase were consistently lower than those of protease, yet in our original survey the prevalences of sensitisation to these enzymes were very similar to that of protease 6. Findings from animal experiments suggest that non-protease enzymes, when encountered together with a protease, are more potent than proteases and would induce sensitisation at lower thresholds 7. Modern enzyme-containing detergent washing powders almost always contain a variety of enzymes making it difficult, if not impossible, to examine the individual effects of single enzyme types in humans.…”

Section: Discussionmentioning

confidence: 77%

Detergent protease exposure and respiratory disease: case–referent analysis of a retrospective cohort

Brant

Upchurch²,

Tongeren

et al. 2009

Occup Environ Med

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These findings provide strong evidence of an association between detergent enzyme exposure and the development of respiratory disease in an occupational setting. Using the routinely collected information on specific sensitisation and the close attention to workplace exposures that are characteristic of this industry, it should be possible to derive meaningful occupational exposure standards for most detergent enzymes.

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Section: Discussionmentioning

confidence: 77%

Detergent protease exposure and respiratory disease: case–referent analysis of a retrospective cohort

Brant

Upchurch²,

Tongeren

et al. 2009

Occup Environ Med

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“…Patients with asthma and rhinitis often show multiple sensitization [9]; nevertheless sensitization of this type has been infrequently reported in respiratory disease of occupational origin. The sporadic cases described concern cross-reactive allergens, as occurs between isocyanates or metals [16, 17] and between some enzymes [2, 18, 19]. The possibility of presenting double or multiple sensitivity against unrelated antigens is rarely cited.…”

Section: Discussionmentioning

confidence: 99%

Occupational Asthma Related to Mouse Allergen Exposure and Rhinoconjunctivitis due to Collagenase Inhalation in a Laboratory Technician

Muñoz

Gómez-Ollés²,

Cruz³

et al. 2005

Respiration

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We describe the case of a 27-year-old patient working in a research laboratory, who developed occupational asthma to mouse proteins and presented symptoms of rhinoconjunctivitis caused by manipulation of collagenase. Specific inhalation challenge confirmed the diagnosis of occupational asthma to mouse proteins, whereas specific challenge with collagenase only evoked symptoms of rhinitis and conjunctivitis. SDS-PAGE and Western blot analysis for collagenase showed that the patient’s IgE antibodies bound specifically to a protein with a molecular weight of 92 kDa. Hence, this was an unusual case of double sensitization. The sensitization to collagenase presented in this report may represent a new occupational disease in technicians working in medical or research laboratories.

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“…Animal studies have suggested that proteases potentiate the allergenicity of non-proteases, amylase and lipase. 6 Cellulase has previously been shown by specific bronchial challenge tests to cause occupational asthma, in the pharmaceutical, 7 baking, 8 and enzyme production industries. 9 We now describe for the first time occupational asthma to a cellulase derived from Humicola insolens.…”

Section: Discussionmentioning

confidence: 99%

Occupational asthma caused by cellulase and lipase in the detergent industry

Brant

2004

Occup Environ Med

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Three employees from two different detergent companies were investigated for occupational asthma, using skin prick tests, serum specific IgE, and specific bronchial challenge. Two were challenged with lipase and one with cellulase. All three cases had immunological evidence of sensitisation to the detergent enzymes with which they worked. Bronchial challenge in each provoked a reproducible dual asthmatic response, which reproduced their work related symptoms. These are the first reported cases of occupational asthma attributable to cellulase and lipase in the detergent industry. Four of the most common enzymes used in this industry have now been reported to cause occupational asthma; continued vigilance and caution are needed when working with these or other enzymes.

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Proteolytic detergent enzymes enhance the allergic antibody responses of guinea pigs to nonproteolytic detergent enzymes in a mixture: Implications for occupational exposure☆☆☆★★★

Cited by 30 publications

References 27 publications

Detergent protease exposure and respiratory disease: case–referent analysis of a retrospective cohort

Detergent protease exposure and respiratory disease: case–referent analysis of a retrospective cohort

Occupational Asthma Related to Mouse Allergen Exposure and Rhinoconjunctivitis due to Collagenase Inhalation in a Laboratory Technician

Occupational asthma caused by cellulase and lipase in the detergent industry

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