“…Interestingly, the human hippocampus of Alzheimer's disease patients shows increased levels of pro-MMP-9 near the amyloid plaques (Backstrom et al, 1996) and the same increase was reported in amyloidpositive beagle brains (Lim et al, 1997). In addition, levels of circulating MMP-9 are significantly elevated in the plasma of Alzheimer's disease patients compared (Parvathy et al, 1997) Batimastat (BB-94) Broad spectrum MMP and TACE TAPI-2 Zn 2+ -dependent MP TAPI (-1) Collagenase, gelatinase, ADAM-10, TACE (Schwager et al, 1998;Schwager et al, 1999) ANF-R / EDTA MP (Abe and Misono, 1992) AR / Batimastat (BB-94) Broad spectrum MMP and TACE (Vecchi et al, 1998;Brown et al, 1998 MMP-1, MMP-8 > MMP-9 > MMP-3 Not inhibited by TAPI(-1) EGF / EDTA, EGTA MP (Dempsey et al, 1997) Batimastat (BB-94) Broad spectrum MMP and TACE FcyRIII CD16 GI5402 MMP-1,-3,-9,-13 and TACE (Dekkers et al, 2000) O-phen MP (Bazil and Strominger, 1994) (Galon et al, 1998) RU36156 MMP-8, MMP-9 and TACE (Galon et al, 1998;Mota et al, 2004) 168 B. Cauwe et al …”