Proteolytic activity of IgG-antibodies of mice, immunized by calf thymus histones

Kit, Yu. Ya.; Korniy, Natalya; Kril, Iryna; Magorivska, Iryna; Tkachenko, V.V.; Rostyslav, Bilyy; Stoika, Rostyslav

doi:10.15407/ubj86.02.079

Ukr.Biochem.J.

2014

DOI: 10.15407/ubj86.02.079

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Proteolytic activity of IgG-antibodies of mice, immunized by calf thymus histones

Yu. Ya. Kit¹,

Natalya Korniy²,

Iryna Kril³

et al.

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2016

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The characteristics of antibodies of mice immunized by human unconventional myosin 1c

Myronovskij¹,

Boiko²,

Chumak³

et al. 2016

Ukr.Biochem.J.

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Specific antibodies produced against a protein of interest are invaluable tools for monitoring the protein structure, intracellular location and biological activity. Inoculation of murine lymphoma cells into the peritoneal cavity of immunized mice provides generation of ascitic fluid containing a significant amount of antibody with desired antigen specificity. Here we demonstrated that the intraperitoneal administration of murine lymphoma NK/Ly cells in mice immunized with 48 kDa isoform of human blood serum unconventional myosin 1c leads to generation of ascitic fluid that contained specific IgG-antibodies. These antibodies were capable of binding of the unconventional myosin 1c isolated from blood serum of patients with multiple sclerosis, rheumatoid arthritis and systemic lupus erythematosis, and could be used for diagnostics of several autoimmune diseases, the multiple sclerosis in particular.

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The characteristics of antibodies of mice immunized by human unconventional myosin 1c

Myronovskij¹,

Boiko²,

Chumak³

et al. 2016

Ukr.Biochem.J.

View full text Add to dashboard Cite

show abstract

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Proteolytic activity of IgG-antibodies of mice, immunized by calf thymus histones

Cited by 1 publication

References 29 publications

The characteristics of antibodies of mice immunized by human unconventional myosin 1c

The characteristics of antibodies of mice immunized by human unconventional myosin 1c

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