Abstract:In striated muscle myosin, a proteolysis site at the 25-50 kDa junction, susceptible in the filament and efficiently protected by nucleotides, is similarly protected when myosin is monomeric. Kinetic studies at low ionic strength show a close relationship between LC2 cleavage or degradation rate and cleavage of the 25-50 kDa heavy chain site. The myosin-[(T)-LC2'] species forms normal reconstituted filaments but its 25-50 kDa site susceptibility is closer to that of monomeric myosin, thus becoming practically … Show more
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