Abstract:The concentrations of Pro-Gly-Pro-Leu (PGPL) tetrapeptide and its metabolites (Gly-Pro-Leu, Pro-Gly-Pro, Gly-Pro, and Pro-Gly) in various rat-brain compartments (hippocampus, cerebellum, cortex) were shown to be time-dependent after intranasal administration. The maximum concentrations of [ 3 H]-labeled PGPL and its degradation products in rat brain were observed after 40 min and amounted to 0.07% of the administered dose. The maximum concentrations of PGPL in the cerebellum, hippocampus, and cortex were 2.37,… Show more
scite is a Brooklyn-based organization that helps researchers better discover and understand research articles through Smart Citations–citations that display the context of the citation and describe whether the article provides supporting or contrasting evidence. scite is used by students and researchers from around the world and is funded in part by the National Science Foundation and the National Institute on Drug Abuse of the National Institutes of Health.